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Table 1 Respiratory parameters

From: Adjusting tidal volume to stress index in an open lung condition optimizes ventilation and prevents overdistension in an experimental model of lung injury and reduced chest wall compliance

Parameters

T0

T1

T2

T3

T4

VT

Pplat-group

8 (0)

5.8 (1.1)*

5.7 (0.9)*

5.6 (0.8)*

5.4 (0.8)*

SI-group

 

7.2 (0.2)

7.2 (0.2)

7.2 (0.8)

7.3(0.7)

P-value

8 (0)

0.02

0.04

0.3

0.002

RR

Pplat-group

22 (2)

32 (3)

35 (0)

35 (0)*

35 (0)*

SI-group

22 (2)

31 (3)

33 (2)

32 (1)

31 (1)

P-value

0.79

0.07

0.10

0.04

<0.001

VE

Pplat-group

5.4 (0.2)

5.8 (0.2)*

5.9 (0.2)*

6.2 (0.2)*

6.4 (0.2)*

SI-group

5.5 (0.2)

6.1 (0.2)

6.8 (0.1)

7.3 (0.3)

7.3 (0.2)

P-value

0.48

0.001

0.001

0.001

0.001

SI

Pplat-group

1.05 (0.08)

0.90 (0.12)

0.95 (0.13)

0.97 (0.13)

1.03 (0.12)

SI-group

1.01 (0.04)

1.01 (0.06)

0.99 (0.06)

0.98 (0.05)

0.99 (0.07)

P-value

0.58

0.29

0.66

0.95

0.42

Pplat

Pplat-group

18 (2)

29 (3)*

31 (2)*

30(1)*

30 (1)*

SI-group

18 (3)

35 (3)

35 (2)

36 (2)

35 (2)

P-value

0.91

0.001

0.002

0.001

0.001

PTPEE

Pplat-group

2(1)

5 (3)

6 (3)

6 (3)

5(3)

SI-group

2 (1)

4 (2)

4 (2)

4 (3)

5 (4)

P-value

0.81

0.34

0.32

0.45

0.61

PTP EI

Pplat-group

7 (1)

15 (2)

15 (2)

16 (2)

17 (1)

SI-group

6 (2)

17 (3)

17 (3)

18 (2)

18 (3)

P-value

0.56

0.49

0.17

0.22

0.42

ΔPTP

Pplat-group

5 (2)

11 (6)

9 (2)

10 (3)

10 (3)

SI-group

5 (2)

13 (2)

12 (4)

14 (4)

13 (4)

P-value

0.74

0.81

0.08

0.18

0.40

Crs

Pplat-group

20 (3)

13 (4)

14 (3)

14 (3)

13 (3)

SI-group

21 (3)

14 (2)

15 (2)

16 (2)

15 (3)

P-value

0.72

0.54

0.63

0.31

0.35

Ccw

Pplat-group

80 (6)

34 (4)

33 (3)

32 (3)

32 (3)

SI-group

80 (5)

34 (3)

33 (5)

33 (4)

34 (4)

P-value

0.92

0.89

0.86

0.24

0.19

CL

Pplat-group

46 (3)

18 (1)

18 (4)

18 (5)

15 (3)

SI-group

50 (5)

18 (3)

18 (3)

18 (2)

18(2)

P-value

0.51

0.69

0.73

0.59

0.24

pH

Pplat-group

7.45 (0.0)

7.25 ( 0.0)*

7.21 (0.0)*

7.18 (0.0)*

7.19 (0.0)*

SI-group

7.45 (0.1)

7.32 (0.0)

7.34 (0.1)

7.34 (0.0)

7.34 (0.1)

P-value

0.68

0.09

0.004

0.003

0.01

PaO2/FiO2

Pplat-group

482 (122)

151 (40)

179 (49)

225 (80)

220 (82)

SI-group

515 (50)

188 (68)

220 (62)

214 (68)

230 (78)

P-value

0.58

0.31

0.52

0.81

0.73

PaCO2

Pplat-group

44 (7)

68 (15)

78 (15)*

83 (12)*

82 (19)*

SI-group

47 (8)

54 (7)

56 (6)

54 (7)

53 (7)

P-value

0.54

0.12

0.02

0.002

0.01

  1. Time-points T0: Baseline measurement, 10 minutes after protocolized baseline ventilatory parameters, before lung injury; T1: 60; T2: 120; T3: 180; and T4: 240 minutes after protocolized ventilatory parameters (open lung PEEP and protocolized VT corresponding to the study group) were adjusted. Data are presented as mean (SD). VT: tidal volume (ml/kg); RR: respiratory rate (bpm); VE: minute volume (L); SI: stress index; Pplat: plateau pressure (cmH2O); PTPEE: end-expiratory transpulmonary pressure (cmH2O); PTPEI: end-inspiratory transpulmonary pressure (cmH2O); ΔPTP: delta-transpulmonary pressure (end-inspiratory – end-expiratory) (cmH2O); Crs: respiratory system compliance (ml/cmH2O); CL: lung compliance (ml/cmH2O); Ccw: chest wall compliance (ml/cmH2O); pH: acid-based state; PaO2/FiO2: arterial oxygen tension to inspiratory oxygen fraction index (mmHg); PaCO2: arterial carbon dioxide tension (mmHg). *When significant difference (P <0.05) between Pplat-group versus SI-group.
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Critical Care

ISSN: 1364-8535