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Table 5 Risk factors for mortality among patients with proven or putative invasive aspergillosis

From: Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes

Variable

Univariable analysis

Multivariable analysis

 

P -value

OR (95% CI)

P-value

OR (95% CI)

Age, yr

0.008

1.023 (1.006 to 1.040)

0.001

1.034 (1.014 to 1.055)

Male

0.264

0.751 (0.455 to 1.241)

  

BMI

0.024

1.069 (1.009 to 1.133)

  

Septic shock

0.689

1.158 (0.565 to 2.374)

  

Pneumonia

0.880

0.948 (0.476 to 1.888)

  

Primary brain injury

0.216

0.218 (0.020 to 2.437)

  

Acute cardiac failure

0.225

3.655 (0.450 to 29.660)

  

Sepsis on admission

0.110

1.503 (0.912 to 2.478)

  

APACHEa II score at admission

0.003

1.049 (1.017 to 1.083)

  

Diabetes

0.576

1.211 (0.619 to 2.371)

  

Chronic heart disease

0.030

3.890 (1.140 to 13.266)

  

COPD

0.605

0.872 (0.520 to 1.463)

  

Liver failure

0.070

2.749 (0.922 to 8.192)

  

HIV

0.564

0.441 (0.027 to 7.132)

  

Smoking

0.937

1.029 (0.509 to 2.078)

  

Alcohol abuse

0.298

0.639 (0.276 to 1.483)

  

Chronic dialysis

0.148

4.615 (0.582 to 36.603)

  

Bone marrow transplant

0.013

3.875 (1.326 to 11.327)

0.039

3.352 (1.060 to 10.598)

Solid tumor

0.085

2.241 (0.894 to 5.617)

  

Cancer

0.769

1.101 (0.579 to 2.094)

  

Neutropenia

0.646

0.827 (0.368 to 1.858)

  

Chemotherapy/radiotherapy

0.525

0.802 (0.405 to 1.586)

  

Solid organ transplant

0.877

1.055 (0.534 to 2.084)

  

Corticosteroids

0.248

1.376 (0.801 to 2.366)

  

Immune deficit

0.117

0.342 (0.090 to 1.306)

  

Aspergillus species

0.040

2.183 (1.038 to 4.592)

  

Lung involvement

0.998

1.001 (0.300 to 3.340)

  

SOFA score at diagnosis

<0.001

1.180 (1.107 to 1.256)

<0.001

1.140 (1.062 to 1.224)

Vasopressor therapy at diagnosis

<0.001

4.309 (2.299 to 8.078)

  

Mechanical ventilation at diagnosis

<0.001

6.498 (2.590 to 16.303)

0.009

3.916 (1.408 to 10.891)

Renal replacement therapy at diagnosis

<0.001

3.293 (1.895 to 5.722)

0.011

2.339 (1.212 to 4.516)

  1. aAPACHE, Acute Physiology and Chronic Health Evaluation; BMI, Body mass index; CI, Confidence interval; COPD, Chronic obstructive pulmonary disease; IA, Invasive aspergillosis; OR, Odds ratio; RRT, Renal replacement therapy; SOFA, Sequential Organ Failure Assessment.
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