Table 2 ACTH Test 1 and 2 classified according to groups of Δ cortisol <, ≥ 250 n M
Test 1 Δ <250 n M | Test 1 Δ ≥250 n M | Test 2 Δ <250 n M | Test 2 Δ ≥250 n M | P Δ cortisol, time, interaction | |
|---|---|---|---|---|---|
n = 17 | n = 42 | n = 14 | n = 45 | ||
ACTH, pM | 3.1 (1.1-18.0) | 1.5 (1.1-15.0) | 6.0 (1.1-14.0) | 3.8 (1.0-8.9) | 0.001, 0.025, 0.72 |
Baseline cortisol, nM | 470 (200–1,355) | 430 (75–2,670) | 655 (335–1,890) | 495 (35–2,670) | 0.021, 0.12, 0.30 |
Baseline cortisol/ACTH, nM/pM | 148 (36–250) | 238 (14–2,054) | 109 (48–1,718) | 126 (35–2,054) | 0.029, 0.16, 0.14 |
Baseline free cortisol, nM | 77 (63–357) (n = 9) | 86 (38–256) (n = 14) | 154 (114–252) (n = 6) | 75 (4–151) (n = 20) | 0.001, 0.91, 0.19 |
Baseline free cortisol/ACTH, nM/pM | 22 (9–38) | 39 (16–89) | 26 (11–43) | 17 (4–35) | 0.042, 0.10, <0.001 |
Δ cortisol, nM | 140 (−50-245) | 388 (260–4,015) | 177 (−80-230) | 425 (255–965) | n.a., 0.45, 0.093 |
Δ free cortisol, nM | 59 (−71-124) | 151 (74–678) | 40 (−34-99) | 133 (32–233) | <0.001, 0.15, 0.16 |
CBG, mg/L | 23 (6–43) | 29 (13–63) | 39 (4–60) | 41 (21–65) | 0.060, <0.001, 0.90 |
Albumin, g/L | 13 (6–32) | 17 (6–24) | 16 (12–28) | 20 (8–32) | 0.25, <0.001, 0.89 |
Days from admission to test | 1 (0–50) | 3 (0–44) | 25 (9–49) | ||
Days between tests | n.a. | n.a. | 18 (8–34) | 16 (8–43) | |
Days after stopping hydrocortisone | n.a. | n.a. | 7 (5–12) | 7 (5–14) | 0.75a |