Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?

Table 1 Baseline characteristics of the study cohort^a

	All			KDIGO 0			KDIGO 1 or 2
Variable	n = 42	%	Median (IQR)	n = 26	%	Median (IQR)	n = 16	%	Median (IQR)	P -value
Elective surgery	41	97.6		26	100		15	93.8		0.38
EF <35%	4	9.5		1	3.9		3	18.8		0.15
Preoperative creatinine ≥1.2 mg/dl	26	61.9		8	30.8		9	56.3		0.1
CHF	18	42.9		14	53.9		4	25		0.11
COPD	14	33.3		10	38.5		4	25		0.51
IDDM	10	23.8		6	23.1		4	25		1
Age, yr			72 (65 to 76)			66.5 (61 to 73)			75 (72 to 81)	0.04
BMI, kg/m²			29.6 (25.7 to 33.1)			30.1 (26.1 to 33.2)			29.1 (25.7 to 33.1)	0.73
CPB time, min			126.5 (100 to 154)			115.5 (97 to 147)			134.5 (111 to 176.5)	0.17
ACC time, min			75.5 (67 to 103)			70.5 (61–86)			77 (71.5 to 115)	0.12
pRBCs, U			1 (0 to 2)			1 (0 to 2)			0.5 (0 to 3)	0.98
Hospital LOS, days			12 (3 to 33)			12 (9 to 14)			11.5 (9 to 17.5)	0.58
ICU LOS, days			2.5 (1 to 5)			1 (1 to 4)			4.5 (2.5 to 5.5)	0.02

^aACC, Aortic cross-clamping; BMI, Body mass index; CHF, Congestive heart failure; COPD, Chronic obstructive pulmonary disease; CPB, Cardiopulmonary bypass; EF, Left ventricular ejection fraction; ICU, Intensive Care Unit; IDDM, Insulin-dependent diabetes mellitus; LOS, Length of stay; pRBCs, Packed red blood cells. Descriptive statistics are displayed as the distribution of the potential risk factors of acute kidney injury separately for the total cohort and for the subcohorts of Kidney Disease: Improving Global Outcomes (KDIGO) stage 0 and KDIGO stage 1 or 2. In the upper rows, categorical preoperative variables are displayed as numbers and ratios of each cohort; in the lower rows, continuous and intraoperative variables are presented as median and interquartile range (IQR, 25th to 75th percentiles), BMI as mean and 95% CI.

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