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Table 3 Area under the receiver operating characteristic curve values for acute kidney injury detection by biomarkers a

From: Evaluation of urinary tissue inhibitor of metalloproteinase-2 in acute kidney injury: a prospective observational study

 

AKI

Severe AKI

Septic AKI

Septic severe AKI

Plasma NGAL

0.84 (0.74 to 0.91)b

0.87 (0.76 to 0.93)b

0.94 (0.88 to 0.97)c

0.92 (0.84 to 0.96)d

Plasma IL-6

0.72 (0.61 to 0.81)

0.70 (0.57 to 0.80)

0.88 (0.79 to 0.93)d

0.84 (0.74 to 0.91)

Plasma EPO

0.63 (0.51 to 0.74)

0.71 (0.57 to 0.82)

0.65 (0.52 to 0.77)

0.78 (0.66 to 0.87)

Urinary TIMP-2

0.75 (0.63 to 0.84)

0.81 (0.66 to 0.90)

0.78 (0.65 to 0.88)

0.84 (0.68 to 0.92)

Urinary NAG

0.84 (0.73 to 0.90)e

0.88 (0.78 to 0.94)b

0.84 (0.72 to 0.91)d

0.90 (0.81 to 0.95)d

  1. aAKI, Acute kidney injury; EPO, Erythropoietin; IL, Interleukin; NAG, N-acetyl-β-d-glucosaminidase; NGAL, Neutrophil gelatinase-associated lipocalin; TIMP-2, Tissue inhibitor of matrix metalloproteinase-2. bP < 0.05 vs. IL-6 and EPO; cP < 0.05 vs. EPO, TIMP-2 and NAG; dP < 0.05 vs. EPO; eP < 0.05 vs. EPO and TIMP-2. Data are areas under the receiver operating characteristic curve with 95% confidence intervals.