Table 2 Unadjusted and adjusted outcome data extracted for the included studies
From: Arterial hyperoxia and mortality in critically ill patients: a systematic review and meta-analysis
| Â | Unadjusted data | Adjusted data | ||||
|---|---|---|---|---|---|---|
| Â | Hyperoxia | Not exposed to hyperoxia | Normoxia | OR [95% CI] a | Comparator group | Variables in the model |
ICU patients | Â | Â | Â | Â | Â | |
de Jonge et al. 2008 [16] | NA | NA | NA | 1.23 [1.13-1.34] (upper quintile) | PaO2 66-80 mmHg | Age, SAPS II, GCS <15, admission type, individual hospital |
Eastwood et al. 2012 [20] | 58,855/17,225b | 54,406/22,164 | NA | 0.73 [0.68-0.78] (upper decile) | PaO2 75-85 mmHg | Site, APACHE III risk of death (O2 component removed), FiO2, year |
Suzuki et al. 2013 [2] | 21/11 | 13/6 | NA | NA | ||
Suzuki et al. 2014 [32] | 35/16 | 45/9 | NA | 0.35 [0.12-1.06] | Conservative group | APACHE III score, primary diagnosis, reason for mechanical ventilation |
Post-cardiac arrest | Â | Â | Â | Â | ||
Bellomo et al. 2011 [21] | 531/754 | 4,609/6,214 | 1,008/911 | 1.2 [1.0-1.5] | Normoxia | APACHE III risk of death (O2 component removed), treatment limitation, year of admission, lowest glucose in the first 24 h, hospital admission from home, hypoxia/poor O2 exchange |
Ihle et al. 2013 [31]c | 11/7 | 137/78 | 129/60 | NA | ||
Janz et al. 2012 [35]c | 15/31 | 66/62 | NA | 1.44 [1.03-2.02]d | Not defined | Age, time to return of spontaneous circulation, presence of shock, bystander CPR, initial rhythm |
Kilgannon et al. 2010 [17] | 424/732 | 2,341/2,829 | 639/532 | 1.8 [1.5-2.2] | Not exposed to hyperoxia | Age, ED origin, non-independent functional status at admission, chronic renal failure, active chemotherapy, high heart rate in ICU, hypotension at ICU arrival, hypoxia exposure |
Lee et al. 2014 [36]c | 39/14 | 111/49 | NA | 0.604 [0.225-1.621] | PaO2 116.9-134.9 mmHg | Age, witness of collapse, hypertension, first monitored rhythm, etiology of cardiac arrest, time to return of spontaneous circulation, time from initiation of therapeutic hypothermia to achieve target temperature, SOFA score (respiratory component removed) |
Nelskyla et al. 2013 [37] | 20/29 | 24/46 | NA | NA | ||
Stroke | Â | Â | Â | Â | Â | Â |
Rincon (a) et al. 2014 [19] | 182/268 | 1,252/1,192 | 582/502 | 1.22 [1.04-1.48] | Normoxia | Age, GCS, intracranial hemorrhage diagnosis, hypothermia at ICU admission, hypotension or hypertension, organ dysfunctions |
Young et al. 2012 [23] | 101/163 | 1,028/1,351 | 927/1,188 | NA | ||
Traumatic brain injury | Â | Â | Â | |||
Asher et al. 2013 [33] | 87/45 | 23/38 | 4/10 | 3.1 [0.4-24.4] (for survival) | Not exposed to hyperoxia | Age, sex, ISS, politrauma, hematocrit >30%, any PaCO2 ≥35 mmHg, chest injury, ARDS in the first 72 h |
Brenner et al. 2012 [18] | 459/207 | 651/230 | 587/191 | 1.56 [1.18-2.07] | Normoxia | Age, sex, ISS, mechanism of injury, admission GCS, admission systolic blood pressure |
Davis et al. 2009 [34] | 210/129 | 2,342/739 | 1,602/479 | 2.0 [1.4-2.7] | Not exposed to hyperoxia | GCS, age, sex, hypotension, ISS, intubation, penetrating mechanism, head Abbreviated ISS, eucapnia, base deficit |
Raj et al. 2013 [22] | 423/144 | 380/169 | 270/105 | 0.94 [0.65-1.36] | Normoxia | APACHE II (O2 component removed), year of admission, emergency operation, intracranial pressure monitoring, controlled hypothermia, platelet count |
Rincon (b) et al. 2014 [38] | 176/80 | 645/311 | 316/87 | 1.50 [1.02-2.40] | Not exposed to hyperoxia | Age, comorbidities, GCS, MAP, anemia, organ dysfunction, gender, non-white race, ED boarder status, ICP monitor, abnormal pH, hospital characteristics |