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Table 2 Patients with septic shock included in the meta-analysis

From: Comparison of the effects of albumin and crystalloid on mortality in adult patients with severe sepsis and septic shock: a meta-analysis of randomized clinical trials

Authors Year Definition of septic shock Sample size of septic shock Non-survival of septic shock Non-survival of albumin group with septic shock (events/total) Non-survival of crystalloid group with septic shock (events/total)
Rackow et al. [13] 1983 Patients were considered septic shock if (1) blood cultures were positive and/or an infected focus was identified, (2) systolic intra-arterial pressure of less than 90 mmHg, or a cardiac index less than 2.2 L/min.m2, or a serum arterial lactate greater than 18 mg/dl, and pulmonary artery wedge pressure less than 15 mmHg. 18 11 5/7 3/4
Metildi et al. [15] 1984 N/A N/A N/A N/A N/A
The SAFE study investigators [6] 2010 Septic shock was defined by the presence of a defined focus of infection and at least two of the four systemic inflammatory response syndrome criteria and infection-related cardiovascular sequential organ failure assessment score of 3 or 4. 438 160 70/209 90/229
The CRISTAL study investigators [14] 2013 Septic shock was defined by sepsis induced acute hypovolemia. Hypovolemia was defined by the combination of (1) hypotension: systolic arterial pressure of less than 90 mm Hg, mean arterial pressure of less than 60 mm Hg, orthostatic hypotension, or a delta pulse pressure of 13% or higher; (2) evidence for low filling pressures and low cardiac index as assessed either invasively or noninvasively; and (3) signs of tissue hypoperfusion or hypoxia, including at least two of the following clinical symptoms: a Glasgow coma scale score of less than 12, mottled skin, urinary output of less than 25 mL/h, or capillary refilling time of 3 seconds or longer; and arterial lactate levels higher than 2 mmol/L, blood urea nitrogen higher than 56 mg/dL, or a fractional excretion of sodium of less than 1%. 1553 441 (28-day) 538 (90-day) 19/59 (28-day) 22/59 (90-day) 157/557 (28-day) 197/557 (90-day)
The ALBIOS study investigators [9] 2014 Septic shock was defined by the presence of a defined focus of infection and at least two of the four systemic inflammatory response syndrome criteria and infection-related cardiovascular sequential organ failure assessment score of 3 or 4. 1121 524 (90-day) 243/558 (90-day) 281/563 (90-day)
  1. N/A, not applicable. No detailed description of hemodynamic instability in Metildi et al. [15] trial.