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Table 1 Patient characteristics and outcome

From: Early high protein intake is associated with low mortality and energy overfeeding with high mortality in non-septic mechanically ventilated critically ill patients

 

Septic patients

Non-septic overfed patients

Non-septic non-overfed patients

All patients

Analysis of variance, Kruskal-Wallis test or chi squared test, P -value

n = 117

n = 307

n = 419

n = 843

Mean

SD

Mean

SD

Mean

SD

Mean

SD

 

Male gender, %

64.1

 

60.3

 

64.9

 

63.1

 

0.426

Age, y

64.2

14.2

61.3

17.1

63.2

16.4

62.6

16.4

0.172

Weight, kg

75.6a,b

20.3

74.2a

18.4

78.4b

16.7

76.5

18.0

0.006

Height, cm

172

10.7

172

9.7

173

9.6

172

9.8

0.804

Body mass index, kg/m2

25.4a,b

5.8

25.0a

5.8

26.3b

5.2

25.7

5.5

0.006

Body mass index <18.5, %

6.8

 

7.2

 

2.1

 

4.6

  

Body mass index >30, %

12.8

 

12.7

 

18.5

 

15.3

  

APACHE II score

25.4a

8.3

22.5b

7.5

17.9b

8.1

23.0

7.9

0.001

Respiratory rate, /minuteW

22

6

21

7

21

7

21

7

0.188

VO2, ml/minuteW

264a,b

69

254a

51

278b

60

268

60

<0.001

VCO2, ml/minuteW

227a,b

56

224a

42

233b

51

229

49

0.036

Respiratory quotientW

0.87a,b

0.10

0.89a

0.11

0.84b

0.10

0.86

0.11

<0.001

FiO2, %W, Z

40

40 to 45

40

40 to 45

40

40 to 45

40

40 to 45

0.075

Measured EEx, kcal/d

1,808a,b

359

1,776a

318

1,886b

347

1,835

342

<0.001

Estimated EEy, kcal/d

1,991

415

1,983

365

2,049

368

2,017

375

0.048

Day 4 energy, kcal/d

1,673a

703

2,234b

430

1,337c

608

1,710

699

<0.001

Day 4 intake/measuredEE

0.95a

0.40

1.27b

0.18

0.71c

0.30

0.95

0.38

<0.001

Day 4 protein, g/kg

1.00a

0.53

1.33b

0.28

0.69c

0.43

0.97

0.49

<0.001

Length of ventilationz, d

18

12 to 29

16

10 to 28

17

10 to 28

17

10 to 28

0.495

Length of ICU stayz, d

22

14 to 34

19

12 to 31

20

12 to 31

20

12 to 31

0.516

Length of hospital stayz, d

32

21 to 55

37

22 to 59

35

21 to 59

35

21 to 59

0.544

ICU mortality, %

26.5

 

20.8

 

18.6

 

20.5

 

0.173

Hospital mortality, %

48.7

 

36.5

 

32.0

 

35.9

 

0.004

  1. a, b, cValues in the same row not sharing the same letter are significantly different at P <0.05 in a post-hoc Bonferroni analysis or pairwise comparison on analysis of variance or Kruskal-Wallis test. WValue at time of energy expenditure measurement. xEnergy target defined by indirect calorimetry. yEnergy target defined by Harris Benedict formula +30%. zNon-normally distributed; data presented as median and 25th to 75th percentiles. P-values in bold indicate a significant test result. APACHE, acute physiology and chronic health evaluation; VO2, oxygen uptake; VCO2, carbon dioxide elimination; FiO2, inspired oxygen fraction; EE, energy expenditure.