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Table 1 Baseline characteristics of included studies

From: The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta-analysis

Study N (P/Cntl) Population Age (P/Cntl) Illness severity (P/Cntl) (mean) Modality Intensity Replacement fluid
Reeves and colleagues [23] 30 (14/16) Sepsis syndrome 39/53 (mean) 26.2/24.2 (adults) Plasma filtration 2 PV during first 4 to 6 hours, 3 PV throughout following 28 to 30 hours (total five volumes) FFP/protein electrolyte replacement solution (1:4 ratio)
  22 adults
Eight children
26.3/26.9 (childrena) (PF1000 plasma filter, Gambro, Lund, Sweden)
213 ml/kg (SD 42.2) plasma exchanged
(APACHE II)
Busund and colleagues [24] 106 (54/52) Adults with severe sepsis or septic shock 41/48 (mean) 56.4/53.5 Plasmapheresis One treatment of 30 to 40 ml/kg exchange FFP:5% albumin replacement fluid (1:1 ratio)
  (APACHE III) (PF-0.5 [Lvov, Russia] and DK2-03 [Rjazan, Russia] plasmapheresis machine)
(Repeated once if no clinical improvement)
Mean 1,820 ± 402 ml (first session) and 1,763 ± 312 ml (second session)
Nguyen and colleagues [25] 10 (5/5) Children with thrombocytopenia and multiorgan failure due to sepsis 1 to 16 /3 to 18 (range) 25.7/25.7 Plasma exchange (SPECTRA, Gambro BCT, Lakewood, Co, USA) 1.5 volumes day 1; 1.0 volumes for 14 days) NR
   (PELOD)a
Median of 12 treatments given
Long and colleagues [26] 48 (25/23) Children with severe sepsis 2.8 (1.2 to 9.6) /2.8 (0.9 to 5) NR Plasma filtration 2 PV over first 2 hours (100 ml/kg) followed by 6 PV over the next 30 hours (300 ml/kg) FFP/protein electrolyte replacement solution (1:4 ratio)
  (PF1000 or PF2000 plasma filter, Gambro, Lund, Sweden)
Median (IQR)
  1. APACHE, Acute Physiology and Chronic Health Evaluation; Ctrl, control; FFP, fresh frozen plasma; IQR, interquartile range; NR, not reported; P, plasmapheresis; PELOD, Pediatric Logistic Organ Dysfunction; PV, plasma volume; SD, standard deviation. aResults inferred from published graph.