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Table 4 Clinically orientated primary outcomes

From: Physiological changes after fluid bolus therapy in sepsis: a systematic review of contemporary data

First author Journal Year Control group ICU mortality Hospital mortality Other Intervention group ICU mortality Hospital mortality Other
MacRedmond [ [49]] Quality and Safety in Health Care 2010 Before protocolised resuscitation 19/37    After protocolised resuscitation 10/37   
Pierrakos [ [59]] Intensive Care Medicine 2012 Responders (>10% increase in CI) 13/25    Non-responders (<10% increase in CI) 11/26   
Patel [ [58]] Annals of Pharmacotherapy 2010 Pre-intervention   32/53   Post-intervention, significantly more fluid and less vasoactives   12/59  
Castellanos-Ortega [ [37]] Critical Care Medicine 2010 Pre-intervention 51/96 55/96   Post-intervention, significantly more fluid 117/384 144/384  
Trof [ [64]] Critical Care Medicine 2012 Pulmonary artery catheter-guided resuscitation 13/34 15/34   Transpulmonary thermodilution-guided resuscitation 17/38 21/38  
Hanzelka [ [43]] Supportive Care in Cancer 2013 Pre-intervention    28-day: 38/100 Post-intervention, significantly quicker resuscitation    28-day: 20/100
Jacob [ [44]] Critical Care Medicine 2012 Pre-intervention    30-day: 126/245 Post-intervention, significantly quicker resuscitation with significantly larger volumes of fluid at 6 and 24 hours    30-day: 257/426
  1. CI, cardiac index.