Physiological changes after fluid bolus therapy in sepsis: a systematic review of contemporary data

Table 4 Clinically orientated primary outcomes

First author	Journal	Year	Control group	ICU mortality	Hospital mortality	Other	Intervention group	ICU mortality	Hospital mortality	Other
MacRedmond [ [49]]	Quality and Safety in Health Care	2010	Before protocolised resuscitation	19/37			After protocolised resuscitation	10/37
Pierrakos [ [59]]	Intensive Care Medicine	2012	Responders (>10% increase in CI)	13/25			Non-responders (<10% increase in CI)	11/26
Patel [ [58]]	Annals of Pharmacotherapy	2010	Pre-intervention		32/53		Post-intervention, significantly more fluid and less vasoactives		12/59
Castellanos-Ortega [ [37]]	Critical Care Medicine	2010	Pre-intervention	51/96	55/96		Post-intervention, significantly more fluid	117/384	144/384
Trof [ [64]]	Critical Care Medicine	2012	Pulmonary artery catheter-guided resuscitation	13/34	15/34		Transpulmonary thermodilution-guided resuscitation	17/38	21/38
Hanzelka [ [43]]	Supportive Care in Cancer	2013	Pre-intervention			28-day: 38/100	Post-intervention, significantly quicker resuscitation			28-day: 20/100
Jacob [ [44]]	Critical Care Medicine	2012	Pre-intervention			30-day: 126/245	Post-intervention, significantly quicker resuscitation with significantly larger volumes of fluid at 6 and 24 hours			30-day: 257/426

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