Incidence, risk factors and outcomes of new-onset atrial fibrillation in patients with sepsis: a systematic review

Table 4 Outcomes of new-onset atrial fibrillation in patients with sepsis, severe sepsis or septic shock

Reference	Outcome	Patients with new-onset AF (number of patients with outcome/total)	Patients without new-onset AF (number of patients with outcome/total)	Crude OR	P value	Adjusted OR	P value
Christian et al., 2008 [17]	ICU mortality	11/16 (69%)	102/256 (40%)	3.32 (1.12- 9.84)	0.03
Meierhenrich et al., 2010 [20]	ICU mortality	10/23 (44%)	6/27 (22%)	2.69 (0.79-9.17)	0.14
Meierhenrich et al., 2010 [20]	28-day mortality	9/23 (39%)	6/27 (22%)	2.25 (0.66-7.73)	0.22
Salman et al., 2008 [21]	ICU mortality	12/25 (48%)	15/56 (27%)	2.52 (0.95-6.74)	0.06
	In-hospital mortality	16/25 (65%)	20/56 (38%)	3.20 (1.20-8.55)	0.02
	28-day mortality	18/25 (72%)	21/56 (38%)	4.29 (1.53-11.97)	0.004	3.28 (1.13-9.57)^a	0.03
Walkey et al., 2011 [24]	In-hospital mortality	1629/2896 (56%)	13652/36200 (38%)	2.12 (1.97-2.29)	<.0001	1.07 (1.04-1.11)^b,c	n/a
Walkey et al., 2011 [24]	In-hospital ischemic stroke	75/2896 (3%)	249/36200 (1%)	3.84 (2.96-4.98)	<.0001	2.70 (2.05-3.57)^d	n/a
Wells et al., 2011 [26]	ICU/in-hospital mortality	95/132 (72%)	189/333 (57%)	1.96 (1.26-3.03)	0.002

Data are expressed as absolute numbers (%) unless other specified. ^aAdjusted for the severity of illness at ICU admission measure by the Acute Physiology and Chronic Health Evaluation (APACHE) III predicted mortality rate; ^badjusted for: age, sex, race/ethnicity, history of diabetes mellitus, hypertension, obesity, heart failure, stroke, myocardial infarction, chronic obstructive pulmonary disease, metastatic or hematologic malignancy, number of organ failures, presence of electrolyte disturbance, source of sepsis, type of organ failure, type of pathogenic organism and use of pulmonary artery catheter; ^crelative risk; ^dadjusted for: age, sex, race/ethnicity, history of diabetes mellitus, hypertension, obesity, heart failure, stroke, myocardial infarction, chronic obstructive pulmonary disease, metastatic or hematologic malignancy, number of organ failures, presence of electrolyte disturbance, source of sepsis, type of organ failure, type of pathogenic organism and use of pulmonary artery catheter. AF: atrial fibrillation; ICU: intensive care unit; n/a: not available; OR: odds ratio.

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