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Table 2 Outcomes

From: Extracorporeal life support as bridge to lung transplantation: a systematic review

Author, year Ltx/total patients, n Died before Ltx, n (%) Type of bypass Survival at 1 yr post-LTx, % Length of stay MV, days
post-LTx, days post-LTx
Mason, 2010 [11] 51/51 na na 50% 24 (9 to 55) H na
Bermudez, 2011 [34] 14/17 3 (17%): neurologic dysfunction, thrombosis VV, VA 74% 16 (3 to 40) ICU 12 (2 to 20)
Hammainen, 2011 [38] 13/16 3 (19%): septic MOF VV, VA 92% 22 (3 to 63) ICU na
Shafii, 2012 [41] 14/19 5 (26%): septic MOF 2, DIC 2, anoxic brain injury 1 VV, VA 75% 42 (19 to 175) H 22 (5 to 125)
15 (8 to 42) ICU
Nosotti, 2012 11/11 na VV 87% and 50%b 47.6 ± 21.9 H 27.1 ± 20.7
30 ± 20.4 ICU
Javidfar, 2012 [20] 10/18a 8 (44%): pneumonia 1, MOF 6, CA 1 VV,VA 60% 22 (18 to 33) H na
47 (41 to 52) ICU
George, 2012 [10] 122/122 na na 57.6% 32 (16.5-60) H na
Fuehner, 2012 [26] 20/26 6 (23%): CA 2, septic MOF 4 VV,VA 6-month 80% 38 (20 to 87) H 14 (0 to 64)
18 (1 to 69) ICU
Hoopes, 2013 [32] 31/31 na VA, VV 93% 31 (12 to 86)e H na
Anile, 2013 [36] 7/12 5 (41%) VV, VA 85.7% 29 (15 to 59) H <5
Toyoda, 2013 [33] 24/31 7 (22%) VV,VA 74% 46 median H na
Weig, 2013 [39] 13/26 13 (50%): acute liver failure 7, thoracic bleeding 3, cerebral hemorrhage 1,PE 2 VV,VA 54% na na
Crotti, 2013 [35] 17/25 8 (32%): MOF 3, septic shock 2, cardiogenic shock 2, intestinal ischemia 1 VV,VA 82% and 29%c na 12.2 ± 11.9d
45.3 ± 33.5
Lafarge, 2013 [40] 30/36 6 (17%): GI bleeding 1, DIC 1, cerebral hemorrhage 1, CA 1, septic shock 1, therapeutic limitation 1 VV,VA,CPB 66.5% na na
  1. Data are expressed as mean ± standard deviation or median and range. Mason et al., Nosotti et al., Hoopes et al. and George et al. enrolled transplanted patients. aThree of the eight patients who died had transiently recovered their baseline function and were weaned from ECMO support; they subsequently died before LTx. bECMO group: 87% awake (7 pts); mechanical ventilation ECMO group: 50% (4 pts); c82% patients on ECMO bridge <14 days (early): 29% patients on ECMO bridge >14 days (late); d12.2 ± 11.9 days (early group) −45.3 ± 33.5 (late group). eMean (range). LTx, lung transplant; CA, cardiac arrest; MOF, multi-organ failure; DIC, disseminated intravascular coagulation; GI, gastrointestinal; VV, veno-venous; VA, veno-arterial; CPB, cardiopulmonary by-pass; MV, mechanical ventilation; LOS, length of stay; H, hospital; na, not available.