Extracorporeal life support as bridge to lung transplantation: a systematic review

Chiumello, Davide; Coppola, Silvia; Froio, Sara; Colombo, Andrea; Del Sorbo, Lorenzo

doi:10.1186/s13054-014-0686-7

Critical Care

Table 2 Outcomes

From: Extracorporeal life support as bridge to lung transplantation: a systematic review

Author, year	Ltx/total patients, n	Died before Ltx, n (%)	Type of bypass	Survival at 1 yr post-LTx, %	Length of stay	MV, days
Author, year	Ltx/total patients, n	Died before Ltx, n (%)	Type of bypass	Survival at 1 yr post-LTx, %	post-LTx, days	post-LTx
Mason, 2010 [11]	51/51	na	na	50%	24 (9 to 55) H	na
Bermudez, 2011 [34]	14/17	3 (17%): neurologic dysfunction, thrombosis	VV, VA	74%	16 (3 to 40) ICU	12 (2 to 20)
Hammainen, 2011 [38]	13/16	3 (19%): septic MOF	VV, VA	92%	22 (3 to 63) ICU	na
Shafii, 2012 [41]	14/19	5 (26%): septic MOF 2, DIC 2, anoxic brain injury 1	VV, VA	75%	42 (19 to 175) H	22 (5 to 125)
Shafii, 2012 [41]	14/19	5 (26%): septic MOF 2, DIC 2, anoxic brain injury 1	VV, VA	75%	15 (8 to 42) ICU	22 (5 to 125)
Nosotti, 2012	11/11	na	VV	87% and 50%^b	47.6 ± 21.9 H	27.1 ± 20.7
Nosotti, 2012	11/11	na	VV	87% and 50%^b	30 ± 20.4 ICU	27.1 ± 20.7
Javidfar, 2012 [20]	10/18^a	8 (44%): pneumonia 1, MOF 6, CA 1	VV,VA	60%	22 (18 to 33) H	na
Javidfar, 2012 [20]	10/18^a	8 (44%): pneumonia 1, MOF 6, CA 1	VV,VA	60%	47 (41 to 52) ICU	na
George, 2012 [10]	122/122	na	na	57.6%	32 (16.5-60) H	na
Fuehner, 2012 [26]	20/26	6 (23%): CA 2, septic MOF 4	VV,VA	6-month 80%	38 (20 to 87) H	14 (0 to 64)
Fuehner, 2012 [26]	20/26	6 (23%): CA 2, septic MOF 4	VV,VA	6-month 80%	18 (1 to 69) ICU	14 (0 to 64)
Hoopes, 2013 [32]	31/31	na	VA, VV	93%	31 (12 to 86)^e H	na
Anile, 2013 [36]	7/12	5 (41%)	VV, VA	85.7%	29 (15 to 59) H	<5
Toyoda, 2013 [33]	24/31	7 (22%)	VV,VA	74%	46 median H	na
Weig, 2013 [39]	13/26	13 (50%): acute liver failure 7, thoracic bleeding 3, cerebral hemorrhage 1,PE 2	VV,VA	54%	na	na
Crotti, 2013 [35]	17/25	8 (32%): MOF 3, septic shock 2, cardiogenic shock 2, intestinal ischemia 1	VV,VA	82% and 29%^c	na	12.2 ± 11.9^d
Crotti, 2013 [35]	17/25		VV,VA	82% and 29%^c	na	45.3 ± 33.5
Lafarge, 2013 [40]	30/36	6 (17%): GI bleeding 1, DIC 1, cerebral hemorrhage 1, CA 1, septic shock 1, therapeutic limitation 1	VV,VA,CPB	66.5%	na	na

Data are expressed as mean ± standard deviation or median and range. Mason et al., Nosotti et al., Hoopes et al. and George et al. enrolled transplanted patients. ^aThree of the eight patients who died had transiently recovered their baseline function and were weaned from ECMO support; they subsequently died before LTx. ^bECMO group: 87% awake (7 pts); mechanical ventilation ECMO group: 50% (4 pts); ^c82% patients on ECMO bridge <14 days (early): 29% patients on ECMO bridge >14 days (late); ^d12.2 ± 11.9 days (early group) −45.3 ± 33.5 (late group). ^eMean (range). LTx, lung transplant; CA, cardiac arrest; MOF, multi-organ failure; DIC, disseminated intravascular coagulation; GI, gastrointestinal; VV, veno-venous; VA, veno-arterial; CPB, cardiopulmonary by-pass; MV, mechanical ventilation; LOS, length of stay; H, hospital; na, not available.

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