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Table 2 Hazard ratios (95% CI) of the effect of tranexamic acid on all-cause mortality, bleeding and non-bleeding deaths by day since injury and time from injury to treatment

From: Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial

Days since injury Time to treatment ≤3 h Time to treatment >3 h
  All-cause Bleeding Non- bleeding All-cause Bleeding Non- bleeding
0 0.78 (0.68, 0.90) 0.72 (0.60, 0.86) 0.89 (0.71, 1.11) 1.02 (0.76, 1.36) 1.28 (0.85, 1.93) 0.79 (0.51, 1.22)
1 0.86 (0.72, 1.02) 0.72 (0.55, 0.94) 0.98 (0.78, 1.23) 1.02 (0.80, 1.31) 1.47 (0.97, 2.21) 0.81 (0.59, 1.13)
2 0.86 (0.65, 1.13) 1.01 (0.58, 1.77) 0.82 (0.59, 1.12) 1.16 (0.81, 1.66) 1.61 (0.70, 3.70) 1.08 (0.72, 1.60)
3 0.95 (0.66, 1.37) 0.26 (0.09, 0.78) 1.20 (0.80, 1.81) 1.11 (0.73, 1.71) 2.76 (0.73, 10.39) 0.98 (0.62, 1.55)
4 0.94 (0.61, 1.45) 0.64 (0.18, 2.28) 0.99 (0.63, 1.57) 1.04 (0.62, 1.75) 1.04 (0.21, 5.13) 1.04 (0.60, 1.80)