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Table 2 Hazard ratios (95% CI) of the effect of tranexamic acid on all-cause mortality, bleeding and non-bleeding deaths by day since injury and time from injury to treatment

From: Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial

Days since injury

Time to treatment ≤3 h

Time to treatment >3 h

 

All-cause

Bleeding

Non- bleeding

All-cause

Bleeding

Non- bleeding

0

0.78 (0.68, 0.90)

0.72 (0.60, 0.86)

0.89 (0.71, 1.11)

1.02 (0.76, 1.36)

1.28 (0.85, 1.93)

0.79 (0.51, 1.22)

1

0.86 (0.72, 1.02)

0.72 (0.55, 0.94)

0.98 (0.78, 1.23)

1.02 (0.80, 1.31)

1.47 (0.97, 2.21)

0.81 (0.59, 1.13)

2

0.86 (0.65, 1.13)

1.01 (0.58, 1.77)

0.82 (0.59, 1.12)

1.16 (0.81, 1.66)

1.61 (0.70, 3.70)

1.08 (0.72, 1.60)

3

0.95 (0.66, 1.37)

0.26 (0.09, 0.78)

1.20 (0.80, 1.81)

1.11 (0.73, 1.71)

2.76 (0.73, 10.39)

0.98 (0.62, 1.55)

4

0.94 (0.61, 1.45)

0.64 (0.18, 2.28)

0.99 (0.63, 1.57)

1.04 (0.62, 1.75)

1.04 (0.21, 5.13)

1.04 (0.60, 1.80)