Association between vitamin D deficiency and mortality in critically ill adult patients: a meta-analysis of cohort studies

Table 3 Subgroup and sensitivity analyses for hospital mortality

Analyses	Studies, n	Odds ratio (95% CI)	Ρ _{heterogeneity}	I ²
Subgroup analysis
Total [8],[17]-[22]	7	1.76 (1.38, 2.24)	0.402	2.3%
25(OH)D level as a cutoff for vitamin D deficiency
20 ng/ml [8],[18],[22]	3	2.12 (1.35, 3.34)	0.198	38.3%
15 ng/ml [17]	1	1.72 (1.27, 2.33)	-	-
12 ng/ml [20]	1	1.12 (0.45, 2.70)	-	-
10 ng/ml [21]	1	1.13 (0.18, 7.27)	-	-
Sensitivity analysis
Multicenter [17],[20],[21]	3	1.63 (1.23, 2.17)	0.623	0.0%
Prospective cohort [18],[20],[21]	3	1.83 (1.03, 3.24)	0.241	29.7%
One-study-out method
Amrein [22]	1	1.79 (1.23, 2.70)	0.284	20.5%
Hu [18]	1	1.67 (1.30, 2.15)	0.511	0.0%
Nair [21]	1	1.77 (1.39, 2.26)	0.298	18.3%
Higgins [20]	1	1.82 (1.42, 2.34)	0.396	1.8%
Venkatram [8]	1	1.72 (1.35, 2.19)	0.571	0.0%
Braun [17]	1	1.82 (1.23, 2.70)	0.281	21.0%
Fixed-effects versus random-effects model method
Fixed-effects model	6	1.76 (1.38, 2.24)	0.402	2.3%
Random-effects model	6	1.76 (1.37, 2.26)	0.402	2.3%

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