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Table 4 Diagnostic value of methylglyoxal, C-reactive protein, procalcitonin, interleukin-6, and soluble CD14 subtype for identification of patients with sepsis

From: Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study

Parameter

AUC (S/T0 vs. P/T2)

Cutoff

Sensitivity

1-Specificity

Results of pairwise comparisons

MG, nM

0.993

281.1

0.912

0.000

 

CRP, mg/L

0.791

152.8

0.667

0.148

<0.001***

PCT, μg/L

0.844

1.46

0.772

0.222

0.002**

IL-6, pg/mL

0.898

401.0

0.737

0.037

0.007**

sCD14-ST, pg/mL

0.832

825

0.912

0.333

<0.001***

  1. Receiver operating characteristic (ROC) analysis was performed with suitable parameters in order to create cutoff values to determine the diagnostic value of each parameter with regard to the diagnosis of sepsis (S/T0 versus P/T2). Area under the curve (AUC) comparisons of the related ROC curves refer to pairwise comparisons of each parameter with MG. With regard to symbolism and higher orders of significance: **P <0.01; ***P <0.001. CRP, C-reactive protein; IL-6, interleukin-6; MG, methylglyoxal; ns, not statistically significant; PCT, procalcitonin; sCD14-ST, soluble CD14 subtype.