Figure 3

Methylglyoxal-derived advanced glycation end product (MG-AGE) formation in different inflammatory settings in humans. (a) Comparisons of plasmatic MG-AGE formation in healthy volunteers (n = 30, white bar) and patients with septic shock (n = 60, white-spotted bars in black color). Plasma levels of MG-AGEs in patients with septic shock are presented at sepsis onset (S/T0) and 24 hours (S/T1) and 4 days (S/T2) later. Plasma measurements of MG-AGEs in healthy volunteers were performed once (V/T0). Data in bar charts are presented as medians and 95% confidence intervals (CIs). With regard to symbolism and higher orders of significance: *P <0.05; ***P <0.001. Asterisks refer to pairwise comparisons between healthy volunteers and patients with septic shock at the presented time points. (b) Comparisons of plasma MG-AGE formation in postoperative controls following major abdominal surgery (n = 30, white-striped bars in black color) and patients with septic shock (n = 60, white-spotted bars in black color). Plasma levels of MG-AGEs in patients with septic shock are presented at sepsis onset (S/T0) and 24 hours (S/T1) later. Plasma measurements of MG-AGEs in postoperative controls are presented immediately after the end of the surgical procedure (P/T1) and 24 hours afterwards (P/T2). Data in bar charts are presented as medians and 95% CIs. With regard to symbolism and higher orders of significance: **P <0.01; ***P <0.001. ns, not statistically significant.