Figure 1

Plasma levels of methylglyoxal in different inflammatory settings in humans. (a) Comparison of plasma methylglyoxal measurements in healthy volunteers (n = 30, white bar) and patients with septic shock (n = 60, white-spotted bars in black color). Plasma levels of methylglyoxal in patients with septic shock are presented at sepsis onset (S/T0) and 24 hours (S/T1), 4 days (S/T2), 7 days (S/T3), 14 days (S/T4), and 28 days (S/T5). Plasma methylglyoxal measurements in healthy volunteers were performed once (V/T0). Data in bar charts are presented as medians and 95% confidence intervals (CIs). With regard to symbolism and higher orders of significance: ***P <0.001. Asterisks refer to pairwise comparisons between healthy volunteers and patients with septic shock at the presented time points. (b) Comparisons of plasma methylglyoxal measurements in postoperative controls following major abdominal surgery (n = 30, white-striped bars in black color) and patients with septic shock (n = 60, white-spotted bars in black color). Plasma levels of methylglyoxal in patients with septic shock are presented at sepsis onset (S/T0) and 24 hours (S/T1) later. Plasma methylglyoxal measurements in postoperative controls are presented immediately after the end of the surgical procedure (P/T1) and 24 hours afterwards (P/T2). Data in bar charts are presented as medians and 95% CIs. With regard to symbolism and higher orders of significance: ***P <0.001.