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Table 2 Plasma cytokines and renal function

From: Adenosine, lidocaine and Mg2+improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model

 

Baseline

30 minutes

60 minutes

90 minutes

120 minutes

150 minutes

180 minutes

210 minutes

240 minutes

300 minutes

Interleukin-6 (pg/ml)

          

 Control

6 (4 to 10)

5 (3 to 8)

4 (2 to 6)

32 (19 to 53)

107 (65 to 178)

168 (102 to 279)

 

221 (133 to 366)

174 (105 to 289)

83 (50 to 138)

 ALM

4 (3 to 7)

4 (3 to 7)

6 (4 to 10)

45 (27 to 75)

177 (107 to 293)

272 (164 to 451)

 

339 (204 to 561)

266 (161 to 441)

90 (54 to 149)

Interleukin-10 (pg/ml)

          

 Control

5 (3 to 8)

10 (6 to 17)

327 (201 to 532)

391 (240 to 636)

215 (132 to 350)

213 (131 to 347)

 

392 (241 to 638)

419 (257 to 681)

315 (194 to 512)

 ALM

6 (4 to 11)

14 (8 to 22)

303 (186 to 492)

463 (285 to 754)

341 (209 to 554)

297 (182 to 483)

 

347 (213 to 564)

354 (218 to 576)

383 (235 to 623)

Urinary protein/creatinine ratio (μg/μmol)

          

 Control

7.5 (5.5 to 10.3)

 

7.6 (5.5 to 10.4)

 

9.4 (6.8 to 12.9)

 

10.1 (7.4 to 13.9)

 

10.2 (7.5 to 14.1)

11.1 (8.1 to 15.2)

 ALMa

9.1 (6.6 to 12.5)

 

8.4 (6.1 to 11.5)

 

14.1 (10.1 to 19.3)

 

24.3 (17.7 to 33.4)

 

19.5 (14.2 to 26.7)

14.7 (10.7 to 20.2)

Urinary NAGase/creatinine ratio (U/mmol)

          

 Control

2.2 (1.5 to 3.3)

 

2.0 (1.3 to 3.0)

 

2.2 (1.5 to 3.3)

 

1.8 (1.2 to 2.8)

 

1.8 (1.2 to 2.8)

2.2 (1.4 to 3.3)

 ALMb

2.1 (1.4 to 3.2)

 

2.1 (1.4 to 3.2)

 

3.0 (2.0 to 4.5)

 

6.3 (4.2 to 9.5)

 

6.5 (4.3 to 9.7)

3.0c (2.0 to 4.5)

  1. Data presented as median (95% confidence interval). ALM, adenosine, lidocaine and magnesium; NAGase, N-acetyl-β-d-glucosaminidase. aSignificantly different mean/median level. bSignificantly different change over time between groups. cSignificant difference before/after cessation ALM infusion.