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Figure 1 | Critical Care

Figure 1

From: Adenosine, lidocaine and Mg2+improves cardiac and pulmonary function, induces reversible hypotension and exerts anti-inflammatory effects in an endotoxemic porcine model

Figure 1

Schematic diagram of the study protocol. Pigs were randomly assigned in a blinded manner to one of two groups: Group 1, control (n = 8); Group 2, adenosine, lidocaine and magnesium (ALM; n = 8). Animals were subjected to endotoxemia by infusion of Escherichia coli lipopolysaccharide (LPS) at a rate of 1 μg∙kg–1.hour–1 for 5 hours. As LPS infusion was started, animals were loaded with a high-dose bolus infusion of ALM (ALM(1)) followed by a continuous infusion of ALM (ALM(2)) for 1 hour, after which the formulation was decreased (ALM(3)) to minimize hypotension.

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Critical Care

ISSN: 1364-8535