Table 1 Toxic protein exoproducts of Pseudomonas aeruginosa
Exoproduct | Gene symbol | Pseudomonas genome database locus tag | Secretory type | Activity | Effect on host |
|---|---|---|---|---|---|
Alkaline protease | aprA | PA1249 | I | Proteolysis | Blocks complement activation |
Elastase (LasA and LasB) | lasA and lasB | PA1871 and PA3724 | II | Elastolytic activity | Tissue destruction |
Exotoxin A | toxA | PA1148 | II | ADP-ribosyltransferase | Cytotoxin |
Phospholipase C | plcH and plcN | PA0844 and PA3319 | II | Phospholipase C | Heat-labile hemolysis |
ExoS (exoenzyme S, 49-kDa) | exoS | PA3841 | III | ADP-ribosyltransferase, GAP | Anti-phagocytosis |
ExoT (exoenzyme S, 54-kDa | exoT | PA0044 | III | GAP activity | Blocks wound healing |
ExoU | exoU | - | III | Phospholipase A2 | Cytotoxin, anti-phagocytosis |
ExoY | exoY | PA2191 | III | Adenylate cyclase | Edema formation |