Table 1 Overview of publications used in the meta-analysis
Author | Year of publication | Study population | Study design | Number of patients | Endpoints | Comparison (in meta-analysis) | Study *quality |
|---|---|---|---|---|---|---|---|
Amrein et al. [25] | 2014 | Medical, surgical ICU | Retrospective, cohort | 655 | Sepsis, in-hospital mortality | <50Â nmol/l vs >75Â nmol/l | 7 |
Arnson et al. [21] | 2012 | Medical, surgical ICU | Prospective, cohort | 130 | Infections | ≤50 nmol/l vs >50 nmol/l | 6 |
Aygencel et al. [24] | 2013 | Medical ICU | Prospective, cohort | 201 | Infections, sepsis, in-hospital mortality | <50 nmol/l vs ≥50 nmol/l | 4 |
Braun et al. [5] | 2012 | Medical, surgical ICU | Two-centre, retrospective, cohort | 1,325 | Sepsis, 30-day, in-hospital mortality | ≤37 nmol/l vs ≥75 nmol/l | 8 |
Braun et al. [3] | 2011 | Surgical ICU | Two-centre, retrospective, cohort | 2,399 | Infections, 30-day, in-hospital mortality | ≤37 nmol/l vs ≥75 nmol/l | 8 |
Flynn et al. [22] | 2012 | Medical, surgical ICU | Prospective, cohort | 66 | Infections, sepsis, in-hospital mortality | ≤50 nmol/l vs >50 nmol/l | 2 |
Higgins et al. [23] | 2012 | Medical, surgical ICU | Prospective, cohort | 196 | Infections, sepsis, 30-day mortality | ≤30 nmol/l vs ≥60 nmol/l | 7 |
Lucidarme et al. [12] | 2012 | Medical, surgical ICU | Prospective, cohort | 134 | 30-day mortality | >15- ≤30 vs ≥60 nmol/l | 5 |
Matthews et al. [30] | 2012 | Medical ICU | Prospective, cohort | 258 | In-hospital mortality | ≥10- ≤32 vs 67-97 nmol/l | 3 |
Moromizato et al. [26] | 2014 | Medical, surgical ICU | Two-centre, retrospective, cohort | 3,386 | Sepsis | ≤37 nmol/l vs ≥75 nmol/l | 8 |
Nair et al. [27] | 2012 | Medical ICU | Prospective, cohort | 100 | 30-day-, in-hospital mortality | <25 nmol/l vs ≥50 nmol/l | 6 |
Remmelts et al. [28] | 2012 | Ward, medical ICU | Prospective, cohort | 272 | 30-day mortality | ≤50 nmol/l vs ≥75 nmol/l | 7 |
Su et al. [29] | 2013 | Medical, surgical ICU | Prospective, cohort | 156 | 30-day mortality | ≤37 nmol/l vs ≥75 nmol/l | 6 |
Venkatram et al. [4] | 2011 | Medical ICU | Retrospective, cohort | 437 | Sepsis, in-hospital mortality | ≤50 nmol/l vs ≥75 nmol/l | 4 |