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Table 1 Overview of publications used in the meta-analysis

From: Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: systematic review and meta-analysis

Author Year of publication Study population Study design Number of patients Endpoints Comparison (in meta-analysis) Study *quality
Amrein et al. [25] 2014 Medical, surgical ICU Retrospective, cohort 655 Sepsis, in-hospital mortality <50 nmol/l vs >75 nmol/l 7
Arnson et al. [21] 2012 Medical, surgical ICU Prospective, cohort 130 Infections ≤50 nmol/l vs >50 nmol/l 6
Aygencel et al. [24] 2013 Medical ICU Prospective, cohort 201 Infections, sepsis, in-hospital mortality <50 nmol/l vs ≥50 nmol/l 4
Braun et al. [5] 2012 Medical, surgical ICU Two-centre, retrospective, cohort 1,325 Sepsis, 30-day, in-hospital mortality ≤37 nmol/l vs ≥75 nmol/l 8
Braun et al. [3] 2011 Surgical ICU Two-centre, retrospective, cohort 2,399 Infections, 30-day, in-hospital mortality ≤37 nmol/l vs ≥75 nmol/l 8
Flynn et al. [22] 2012 Medical, surgical ICU Prospective, cohort 66 Infections, sepsis, in-hospital mortality ≤50 nmol/l vs >50 nmol/l 2
Higgins et al. [23] 2012 Medical, surgical ICU Prospective, cohort 196 Infections, sepsis, 30-day mortality ≤30 nmol/l vs ≥60 nmol/l 7
Lucidarme et al. [12] 2012 Medical, surgical ICU Prospective, cohort 134 30-day mortality >15- ≤30 vs ≥60 nmol/l 5
Matthews et al. [30] 2012 Medical ICU Prospective, cohort 258 In-hospital mortality ≥10- ≤32 vs 67-97 nmol/l 3
Moromizato et al. [26] 2014 Medical, surgical ICU Two-centre, retrospective, cohort 3,386 Sepsis ≤37 nmol/l vs ≥75 nmol/l 8
Nair et al. [27] 2012 Medical ICU Prospective, cohort 100 30-day-, in-hospital mortality <25 nmol/l vs ≥50 nmol/l 6
Remmelts et al. [28] 2012 Ward, medical ICU Prospective, cohort 272 30-day mortality ≤50 nmol/l vs ≥75 nmol/l 7
Su et al. [29] 2013 Medical, surgical ICU Prospective, cohort 156 30-day mortality ≤37 nmol/l vs ≥75 nmol/l 6
Venkatram et al. [4] 2011 Medical ICU Retrospective, cohort 437 Sepsis, in-hospital mortality ≤50 nmol/l vs ≥75 nmol/l 4
  1. *Study quality assessed by the Newcastle-Ottawa scale, see S8 in Additional file 1. ICU, intensive care unit.