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Table 3 Glomerular and tubular functional assessment and combined marker analyses a

From: Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds

  Mean (95% CI) (present study) Healthy volunteers bmean (SD)
  ml/min/1.73 m 2 ml/min ml/min
Glomerular filtration rate (n =15) 161 (129 to 193) 180 (141 to 219) 143 (45)
Effective renal plasma flow (n =19) 535 (442 to 628) 594 (484 to 704) 467 (146)
Renal tubular anion secretion (n =15)    
Net secretion of PAH 388 (282 to 494) 428 (306 to 550) 359 (134)
Renal tubular cation secretion (n =10)    
Net tubular secretion of (S)-pindolol 47 (−19 to 113) 46 (−15 to 107) 152 (70)
Net tubular secretion of (R)-pindolol 25 (−16 to 67) 24 (−17 to 66) 132 (45)
Renal tubular reabsorption (n =13)    
Net tubular reabsorption of fluconazole 120 (92 to 148) 135 (100 to 169) 93 (29)
  1. aCI, Confidence interval; PAH, p-Aminohippuric acid; SD, Standard deviation. bTwelve healthy male subjects (mean age, 24 years; mean weight, 72 kg; mean height, 1.78 m) with normal laboratory parameters and a Cockcroft-Gault estimated creatinine clearance >100 ml/min [9].