Table 3 Glomerular and tubular functional assessment and combined marker analyses a
| Â | Mean (95% CI) (present study) | Healthy volunteers bmean (SD) | |
|---|---|---|---|
| Â | ml/min/1.73 m 2 | ml/min | ml/min |
Glomerular filtration rate (n =15) | 161 (129 to 193) | 180 (141 to 219) | 143 (45) |
Effective renal plasma flow (n =19) | 535 (442 to 628) | 594 (484 to 704) | 467 (146) |
Renal tubular anion secretion (n =15) | Â | Â | Â |
Net secretion of PAH | 388 (282 to 494) | 428 (306 to 550) | 359 (134) |
Renal tubular cation secretion (n =10) | Â | Â | Â |
Net tubular secretion of (S)-pindolol | 47 (−19 to 113) | 46 (−15 to 107) | 152 (70) |
Net tubular secretion of (R)-pindolol | 25 (−16 to 67) | 24 (−17 to 66) | 132 (45) |
Renal tubular reabsorption (n =13) | Â | Â | Â |
Net tubular reabsorption of fluconazole | 120 (92 to 148) | 135 (100 to 169) | 93 (29) |