Table 1 Demographic, illness severity and physiological data ^a

Age, yr, mean (95% CI)

36.7 (29.2 to 44.1)

Males, n (%)

12 (60.0)

Height, m, mean (95% CI)

1.74 (1.68 to 1.79)

Weight, kg, mean (95% CI)

80.2 (70.8 to 89.5)

Body surface area, m², mean (95% CI)

1.94 (1.81 to 2.07)

Days in ICU before sampling, mean (95% CI)

4.90 (3.74 to 6.06)

APACHE II score, mean (95% CI)

17.3 (13.7 to 20.8)

Diagnosis, n (%)

 Burns

3 (15.0)

 Trauma (including head injury)

10 (50.0)

 Neurological

3 (15.0)

 Sepsis

3 (15.0)

 Other

1 (5.0)

Mechanically ventilated, n (%)

19 (95.0)

Receiving vasopressor infusion, n (%)

3 (15.0)

Pre-dose HR, beats/min, mean (95% CI)

100 (90.8 to 110)

Pre-dose MAP, mmHg, mean (95% CI)

89.4 (83.0 to 95.8)

Plasma CR, μmol/L, mean (95% CI)

64.5 (53.2 to 75.7)

Urinary CR, mmol/L, mean (95% CI)

5.93 (4.02 to 7.85)

24-hr urinary volume, L, mean (95% CI)

3.10 (2.35 to 3.85)

Urinary pH, mean (95% CI), n =16

6.16 (5.75 to 6.57)

24-hr fluid balance, ml, mean (95% CI)

700 (−126 to 1,527)

24-hr CL_CR, ml/min, mean (95% CI)

168 (139 to 197)

CKD-EPI eGFR, ml/min, mean (95% CI)

128 (113 to 144)