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Table 2 Dosing information and pharmacokinetics of vancomycin in the retrospective cohort (group 1) and in the second cohort (group 2)

From: Decreasing the time to achieve therapeutic vancomycin concentrations in critically ill patients: developing and testing of a dosing nomogram

  Group 1 Group 2
  (79 patients) (25 patients)
Loading dose of vancomycin on day 0, mg 1000 (1000-1500) 1500 (1000-1500)
Loading dose of vancomycin on day 0, mg/kg 14.3 (12.8-17.6) 18.8 (16.7-21.4)
Perfusion dose of vancomycin on day 0, mg 1920 (1512-2400) 2072 (1750-2622)
Total dosing of vancomycin on day 0, mg 3160 (2520-3880) 3584 (2976-4138)
Time interval (h) between vancomycin perfusion and TDM 18 (17-27) 18 (17-19)
Serum vancomycin concentration on day 1, mg/L 20.6 (16.7-26) 24.5 (22.2-27.4)
Clearance of vancomycin on day 1, L/h 5.1 (1.9) NC
  1. Values are expressed as median and interquartile range [Q25-Q75] except for Clearance of vancomycin on day 1 (mean and standard deviation).
  2. TDM, therapeutic drug monitoring; day 0, the day before day 1, corresponding to the day of the administration of vancomycin; NC, not calculated.