Table 2 Dosing information and pharmacokinetics of vancomycin in the retrospective cohort (group 1) and in the second cohort (group 2)
Group 1 | Group 2 | |
|---|---|---|
(79 patients) | (25 patients) | |
Loading dose of vancomycin on day 0, mg | 1000 (1000-1500) | 1500 (1000-1500) |
Loading dose of vancomycin on day 0, mg/kg | 14.3 (12.8-17.6) | 18.8 (16.7-21.4) |
Perfusion dose of vancomycin on day 0, mg | 1920 (1512-2400) | 2072 (1750-2622) |
Total dosing of vancomycin on day 0, mg | 3160 (2520-3880) | 3584 (2976-4138) |
Time interval (h) between vancomycin perfusion and TDM | 18 (17-27) | 18 (17-19) |
Serum vancomycin concentration on day 1, mg/L | 20.6 (16.7-26) | 24.5 (22.2-27.4) |
Clearance of vancomycin on day 1, L/h | 5.1 (1.9) | NC |