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Table 1 Baseline characteristics of the studied population: group 1 (retrospective cohort) and group 2 (second cohort)

From: Decreasing the time to achieve therapeutic vancomycin concentrations in critically ill patients: developing and testing of a dosing nomogram

Demographics

Group 1

Group 2

p

(79 patients)

(25 patients)

Male, number (%)

52 (66.0)

17 (68.0)

ns

Age, years

57.8 (15.5)

59.9 (17.2)

ns

Body weight, kg

77 (70-86)

75 (67.5-87.5)

ns

Body surface area, m2

1.87 (0.16)

1.86 (0.19)

ns

Body mass index, kg/m2

28.1 (25.3-30.4)

25.7 (24.4-30.6)

ns

New simplified acute physiology score

39 (34-50)

43 (37-46)

ns

8 h CLCR on day 1, mL/min/1.73 m2

125.1 (66.5)

120.5 (54.2)

ns

Baseline serum creatinine, mg/mL

0.68 (0.30)

0.68 (0.31)

ns

Lowest serum creatinine, mg/mL*

0.57 (0.20)

0.60 (0.19)

ns

Highest serum creatinine, mg/mL*

0.73 (0.28)

0.81 (0.45)

ns

Patients with serum creatinine increase >0.3 mg/mL, number (%)*

5 (6.3)

1 (4.0)

ns

Patients with ARC on day 1, number (%)

29 (36.7)

10 (40.0)

ns

Mechanical ventilation on day 1, number (%)

79 (100)

25 (100)

ns

Admission days

19 (9-29)

23 (18-30)

ns

Admission group diagnosis, %

   

Trauma admission

44.3

52.0

ns

Surgical admission

16.5

28.0

ns

Medical admission

39.2

20.0

ns

  1. Quantitative variables were expressed as mean (standard deviation) or median (interquartile range) when applied. *During the vancomycin treatment. Augmented renal clearance (ARC) defined as 8 h CLCR >130 mL/min/1.73 m2; 8 h CLCR, 8-hour measured urinary creatinine clearance; ns, non significant.