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Table 1 Baseline characteristics of the studied population: group 1 (retrospective cohort) and group 2 (second cohort)

From: Decreasing the time to achieve therapeutic vancomycin concentrations in critically ill patients: developing and testing of a dosing nomogram

Demographics Group 1 Group 2 p
(79 patients) (25 patients)
Male, number (%) 52 (66.0) 17 (68.0) ns
Age, years 57.8 (15.5) 59.9 (17.2) ns
Body weight, kg 77 (70-86) 75 (67.5-87.5) ns
Body surface area, m2 1.87 (0.16) 1.86 (0.19) ns
Body mass index, kg/m2 28.1 (25.3-30.4) 25.7 (24.4-30.6) ns
New simplified acute physiology score 39 (34-50) 43 (37-46) ns
8 h CLCR on day 1, mL/min/1.73 m2 125.1 (66.5) 120.5 (54.2) ns
Baseline serum creatinine, mg/mL 0.68 (0.30) 0.68 (0.31) ns
Lowest serum creatinine, mg/mL* 0.57 (0.20) 0.60 (0.19) ns
Highest serum creatinine, mg/mL* 0.73 (0.28) 0.81 (0.45) ns
Patients with serum creatinine increase >0.3 mg/mL, number (%)* 5 (6.3) 1 (4.0) ns
Patients with ARC on day 1, number (%) 29 (36.7) 10 (40.0) ns
Mechanical ventilation on day 1, number (%) 79 (100) 25 (100) ns
Admission days 19 (9-29) 23 (18-30) ns
Admission group diagnosis, %    
Trauma admission 44.3 52.0 ns
Surgical admission 16.5 28.0 ns
Medical admission 39.2 20.0 ns
  1. Quantitative variables were expressed as mean (standard deviation) or median (interquartile range) when applied. *During the vancomycin treatment. Augmented renal clearance (ARC) defined as 8 h CLCR >130 mL/min/1.73 m2; 8 h CLCR, 8-hour measured urinary creatinine clearance; ns, non significant.