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Table 2 Changes in blood gas parameters and potassium concentration

From: Levosimendan attenuates multiple organ injury and improves survival in peritonitis-induced septic shock: studies in a rat model

Variables

Group

SOP

SOP + LS

CLP

CLP + Veh

CLP + LS

pH

0 h

7.6 ± 0.01

7.5 ± 0.01

7.6 ± 0.02

7.6 ± 0.01

7.6 ± 0.01

9 h

7.5 ± 0.01

7.5 ± 0.01

7.6 ± 0.01

7.6 ± 0.02

7.6 ± 0.02

18 h

7.6 ± 0.01

7.6 ± 0.01

7.5 ± 0.01

7.5 ± 0.03

7.6 ± 0.01

PaCO2, mmHg

0 h

34 ± 1.7

37 ± 2.3

32 ± 1.7

34 ± 0.4

35 ± 0.7

9 h

36 ± 1

37 ± 1.8

22 ± 0.9*

24 ± 1.4*

24 ± 1.7*

18 h

31 ± 1.2

32 ± 1.4

20 ± 1.3*

21 ± 1.9*

28 ± 1.4†

HCO3-, mM

0 h

30 ± 0.7

31.1 ± 1.1

27.9 ± 0.9

30 ± 0.7

29.9 ± 0.6

9 h

29.4 ± 0.6

29.4 ± 1.1

20.8 ± 0.8*

22.1 ± 1.1*

23.2 ± 0.8*

18 h

27.6 ± 0.7

28.5 ± 1.4

16.7 ± 1*

15.4 ± 1.2*

24.5 ± 1†

Base excess, mM

0 h

7.8 ± 0.5

8.4 ± 0.7

7.3 ± 0.2

7.9 ± 0.8

7.5 ± 0.5

9 h

6.7 ± 0.5

6.7 ± 0.7

1.2 ± 0.7*

2.2 ± 1.1*

3.6 ± 0.5*

18 h

5.4 ± 0.5

6.7 ± 1.1

-3.2 ± 0.8*

-5.5 ± 1.3*

3.2 ± 0.9*†

Potassium, mM

0 h

3.7 ± 0.1

3.9 ± 0.1

3.8 ± 0.1

3.8 ± 0.1

3.9 ± 0.1

9 h

3.6 ± 0.1

4 ± 0.1

3.9 ± 0.1

3.9 ± 0.2

3.9 ± 0.1

18 h

3.6 ± 0.1

3.7 ± 0.2

4.9 ± 0.2*

5.2 ± 0.4*

3.8 ± 0.1†

  1. Depicted are the changes in different groups of SOP (n = 10), SOP + LS (n = 6), CLP (n = 10), CLP + Veh (n = 6) and CLP + LS (n = 12). Data are expressed as mean ± standard error of the mean. *P <0.05 all groups versus SOP; †P <0.05, CLP + LS versus CLP + Veh. CLP: cecal ligation and puncture; LS: Levosimendan; SOP: sham of operation; Veh: vehicle (5% dextrose solution).