Variables | Time point | SOP (n = 10) | SOP + LS (n = 6) | CLP (n = 10) | CLP + Veh (n = 6) | CLP + LS (n = 10) |
---|---|---|---|---|---|---|
Heart rate, beats/minute | 0 h | 388 ± 12 | 367 ± 13 | 334 ± 7 | 350 ± 15 | 369 ± 8 |
3 h | 413 ± 12 | 392 ± 16 | 444 ± 11* | 461 ± 12* | 474 ± 12* | |
9 h | 395 ± 10 | 382 ± 16 | 472 ± 11* | 488 ± 20* | 518 ± 13* | |
18 h | 388 ± 11 | 404 ± 20 | 492 ± 17* | 499 ± 14* | 478 ± 8*†| |
Systolic pressure, mmHg | 0 h | 140.3 ± 2.1 | 141.4 ± 3.3 | 133.7 ± 2.6 | 147 ± 4.9 | 139 ± 2.9 |
3 h | 146.6 ± 2.6 | 144.8 ± 1 | 139.8 ± 2.7 | 146.8 ± 6.1 | 141.8 ± 2.6 | |
9 h | 148.1 ± 2.9 | 142.7 ± 1.9 | 124.7 ± 2.6* | 130 ± 6.8 | 133.8 ± 3.4 | |
18 h | 140.4 ± 3.2 | 146 ± 2.3 | 87.4 ± 5.1* | 88 ± 5.1* | 126.7 ± 4.1†| |
Diastolic pressure, mmHg | 0 h | 106.5 ± 2.6 | 103.9 ± 3.3 | 99.8 ± 2.4 | 111.9 ± 3.9 | 104.2 ± 2.5 |
3 h | 112.5 ± 2.3 | 108.2 ± 2.2 | 109.9 ± 2.5 | 118.4 ± 6.6 | 112.3 ± 2.7 | |
9 h | 112.6 ± 3.5 | 104.6 ± 3 | 102.7 ± 2.6* | 108.3 ± 5.8 | 96 ± 3.5 | |
18 h | 105.8 ± 3.6 | 100.3 ± 4.4 | 66.7 ± 4* | 69.5 ± 3.8* | 83.8 ± 4.3*†| |
Pulse pressure, mmHg | 0 h | 33.8 ± 0.9 | 37.5 ± 1.5 | 33.9 ± 1.1 | 35.1 ± 2.4 | 35.3 ± 0.9 |
3 h | 34.1 ± 0.9 | 36.7 ± 1.6 | 30 ± 1.3 | 28.2 ± 2.3 | 29.5 ± 0.8 | |
9 h | 35.5 ± 0.7 | 38.1 ± 2.2 | 22 ± 1* | 21.6 ± 2* | 37.9 ± 2.7†| |
18 h | 34.6 ± 0.9 | 45.7 ± 2.9* | 20.7 ± 1.8* | 18.6 ± 2.6* | 42.9 ± 1.9*†| |
Pressor response to norepinephrine, % | 0 h | 100 ± 0 | 100 ± 0 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
3 h | 90.8 ± 4.1 | 94.5 ± 4 | 40.8 ± 5.2* | 31.1 ± 3.1* | 33.4 ± 3.3* | |
9 h | 105 ± 3 | 96.4 ± 5.4 | 33.7 ± 3.1* | 29.1 ± 2.5* | 33.9 ± 2.8* | |
18 h | 103 ± 3.2 | 94.7 ± 2.6 | 21.9 ± 1.8* | 19.5 ± 1.2* | 31.1 ± 1.5*†|