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Table 1 Changes in haemodynamic parameters

From: Levosimendan attenuates multiple organ injury and improves survival in peritonitis-induced septic shock: studies in a rat model

Variables

Time point

SOP (n = 10)

SOP + LS (n = 6)

CLP (n = 10)

CLP + Veh (n = 6)

CLP + LS (n = 10)

Heart rate, beats/minute

0 h

388 ± 12

367 ± 13

334 ± 7

350 ± 15

369 ± 8

3 h

413 ± 12

392 ± 16

444 ± 11*

461 ± 12*

474 ± 12*

9 h

395 ± 10

382 ± 16

472 ± 11*

488 ± 20*

518 ± 13*

18 h

388 ± 11

404 ± 20

492 ± 17*

499 ± 14*

478 ± 8*†

Systolic pressure, mmHg

0 h

140.3 ± 2.1

141.4 ± 3.3

133.7 ± 2.6

147 ± 4.9

139 ± 2.9

3 h

146.6 ± 2.6

144.8 ± 1

139.8 ± 2.7

146.8 ± 6.1

141.8 ± 2.6

9 h

148.1 ± 2.9

142.7 ± 1.9

124.7 ± 2.6*

130 ± 6.8

133.8 ± 3.4

18 h

140.4 ± 3.2

146 ± 2.3

87.4 ± 5.1*

88 ± 5.1*

126.7 ± 4.1†

Diastolic pressure, mmHg

0 h

106.5 ± 2.6

103.9 ± 3.3

99.8 ± 2.4

111.9 ± 3.9

104.2 ± 2.5

3 h

112.5 ± 2.3

108.2 ± 2.2

109.9 ± 2.5

118.4 ± 6.6

112.3 ± 2.7

9 h

112.6 ± 3.5

104.6 ± 3

102.7 ± 2.6*

108.3 ± 5.8

96 ± 3.5

18 h

105.8 ± 3.6

100.3 ± 4.4

66.7 ± 4*

69.5 ± 3.8*

83.8 ± 4.3*†

Pulse pressure, mmHg

0 h

33.8 ± 0.9

37.5 ± 1.5

33.9 ± 1.1

35.1 ± 2.4

35.3 ± 0.9

3 h

34.1 ± 0.9

36.7 ± 1.6

30 ± 1.3

28.2 ± 2.3

29.5 ± 0.8

9 h

35.5 ± 0.7

38.1 ± 2.2

22 ± 1*

21.6 ± 2*

37.9 ± 2.7†

18 h

34.6 ± 0.9

45.7 ± 2.9*

20.7 ± 1.8*

18.6 ± 2.6*

42.9 ± 1.9*†

Pressor response to norepinephrine, %

0 h

100 ± 0

100 ± 0

100 ± 0

100 ± 0

100 ± 0

3 h

90.8 ± 4.1

94.5 ± 4

40.8 ± 5.2*

31.1 ± 3.1*

33.4 ± 3.3*

9 h

105 ± 3

96.4 ± 5.4

33.7 ± 3.1*

29.1 ± 2.5*

33.9 ± 2.8*

18 h

103 ± 3.2

94.7 ± 2.6

21.9 ± 1.8*

19.5 ± 1.2*

31.1 ± 1.5*†

  1. Depicted are changes in different groups of SOP (n = 10), SOP + LS (n = 6), CLP (n = 10), CLP + Veh (n = 6) and CLP + LS (n = 12). Data are expressed as mean ± standard error of the mean. *P <0.05, all groups versus SOP; †P <0.05, CLP + LS versus CLP + Veh. CLP, cecal ligation and puncture; LS, Levosimendan; SOP, sham of operation; Veh: vehicle (5% dextrose solution).