Value of further research on IVIG for severe sepsis/septic shock: ENBS and optimal sample size of a trial, according to model for the synthesis of effectiveness evidence (see Table2for detailed specification of the models)
Scenarios for alternative synthesis models of effectiveness evidence
Optimal sample size per arm ( n* )
The ENBS provides the societal payoff to the proposed research. It is computed as the difference between the value of sample information (EVSI) for a particular research design and the costs of sampling. IVIG, intravenous immunoglobulin; ENBS: expected net benefit of sampling.