From: Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial
Scenarios for alternative synthesis models of effectiveness evidence
Maximum ENBS
Optimal sample size per arm ( n* )
M1
£ 136,703,882
1900
M2
£ 687,441,146
1200
M3
£ 1,010,953,361
800
M4a
£ 605,931,859
900
M4b
£ 365,050,246