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Table 4 Value of further research on IVIG for severe sepsis/septic shock: population EVPI estimates (WTP = £20,000), according to alternative synthesis models of effectiveness evidence (see Table 2 for detailed specification of the models)

From: Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial

Scenarios for alternative synthesis models of effectiveness evidence EVPI per patient Population EVPI ( Time horizon  = 10 years)
M1 £1,377 £392,994,216
M2 £3,563 £1,017,023,732
M3 £4,791 £1,367,426,550
M4a £3,146 £897,945,285
M4b £2,113 £603,018,958
  1. EVPI evaluates the expected cost of current uncertainty by accounting both for the probability that a decision based on existing evidence is wrong and for the magnitude of the consequences of making the wrong decisions. EVPI, expected value of perfect information.