Skip to main content

Table 3 Cost-effectiveness of IVIG for severe sepsis/septic shock using the best-fitting and alternative synthesis models of effectiveness evidence (see Table 2 for detailed specification of the models)

From: Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial

(Best-fitting model, M1) Fixed-effect model estimate (IVIG/IVIGAM compared with albumin) considering 3 days duration of IVIG therapy Probability of being cost-effective for cost-effectiveness threshold
Treatment Mean cost Mean QALY ICER £20,000/QALY £30,000/QALY
IVIG £54,901 4.35 £20,850 0.505 0.789
Standard care £45,593 3.90   0.495 0.211
(Alternative model M2) Random-effects model estimate (IVIG/IVIGAM compared with albumin)  
Treatment Mean cost Mean QALY ICER £20,000/QALY £30,000/QALY
IVIG £57,200 4.62 £16,177 0.597 0.707
Standard care £45,593 3.90   0.403 0,295
(Alternative model M3) Random-effects model (IVIG/IVIGAM compared with albumin/no treatments) considering Jadad score = 5  
Treatment Mean cost Mean QALY ICER £20,000/QALY £30,000/QALY
IVIG £55,238 4.39 £19,968 0.502 0.611
Standard care £45,593 3.90   0.498 0.389
(Alternative model M4a) Random-effects model (IVIG/IVIGAM compared with albumin/no treatment) considering a sample size of 339  
Treatment Mean cost Mean QALY ICER £20,000/QALY £30,000/QALY
IVIG £53,518 4.18 £28,520 0.404 0.514
Standard care £45,593 3.90   0.596 0.486
(Alternative model M4b) Random-effects model (IVIG/IVIGAM compared with albumin/no treatment) considering a sample size of infinity  
Treatment Mean cost Mean QALY ICER £20,000/QALY £30,000/QALY
IVIG £50,024 3.76 Dominated 0.275 0.348
Standard care £45,593 3.90   0.725 0.652