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Figure 4 | Critical Care

Figure 4

From: Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial

Figure 4

Longer-term survival of patients after an acute episode of severe sepsis (or septic shock): comparison of parametric survival functions (a) and their modified versions (b) to general population. The curves in Figure 3a investigate the plausibility of the different parametric (Weibull, Exponential and Lognormal) predictions beyond the five years of observed data by comparing these to age-adjusted estimates from the general population. These show that the longer-term mortality parametric estimates for severe sepsis patients become lower than that for the general population. This was considered implausible and, consequently, we modified these distributions by further assuming that the probability of mortality would be the maximum of the predicted parametric distributions and the observed yearly probability of mortality for the general population (age- and sex-adjusted). The ‘modified’ parametric survival functions are reported in Figure 4b.

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