Table 4 Risk of bias in individual studies
From: A systematic review of adult admissions to ICUs related to adverse drug events
| Â | Study | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Evaluated item | [10] | [11] | [12] | [13] | [14] | [15] | [16] | [17] | [18] | [19] | [20] |
Prospective study design? | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Description of the type of studied ICU? | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 |
Complementary information on the setting environment? | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Study size rationale? | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Definition of ADE according to IOM? | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Evaluation of inter-rater reliability for inclusion decision? | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Description of evaluators’ training? | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Description of patients’ screening? | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Description of inclusion/exclusion criteria? | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Description of collected data? | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Description of the drug history collecting method? | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Description of causality assessment method? | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 |
Description of preventability method/criteria? | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
Definition of ADE severity? | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
Description of study duration? | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Results for incidence of ADE requiring ICU admission? | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Results for inter-rater reliability for inclusion decision ? | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Description of the characteristics of patients with ADE (age, gender, severity score at admission, reason of admission, origin of patients)? | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Description of number and classes of drugs suspected to be involved in the ADE responsible for ICU admission? | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Results for causality assessment? | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Results for preventability rate? | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
Results for ADE severity? | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 |
Results for ICU mortality rate of patients with ADE? | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 |
Results for the length of stay for patients with and without ADE (separately)? | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 |
Proportion of items completely reported | 0.58 | 0.42 | 0.33 | 0.71 | 0.46 | 0.38 | 0.79 | 0.67 | 0.63 | 0.46 | 0.63 |