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Table 3 Design and aims of the selected studies

From: A systematic review of adult admissions to ICUs related to adverse drug events

Study Country Study duration Study design Type of hospital Type of ICU Number of patients admitted during studied period Aims of the study
Trunet and colleagues, 1986 [10] France 33 months (August 1978 to April 1981) Prospective monocentre Teaching hospital Multidisciplinary ICU 1,651 Determine cause and effect relationship between drugs and adverse event, severity of DII, role of underlying disease and potential preventability of DII
IGICE, 1987 [11] Italy 6 months Prospective (data collection on a given day each week) ND 27 general ICUs 4,537 Document aspects of ADR epidemiology in 27 general ICUs
Nelson and Talbert, 1996 [12] USA 1 month (July to August 1993) Prospective monocentre Teaching hospital Medical ICU, CCU and internal medicine service 127a Describe the frequency and pattern of drug-related morbidity that results in hospital admission and the extent to which these admissions are avoidable
Darchy and colleagues, 1999 [13] France 12 months (January to December 1994) Retrospective monocentre General hospital (500 beds) Medico-surgical ICU (15 beds), CCU (6 beds) 623 Determine whether aging of the general population and medical advances have altered the incidence, causes and consequences of severe IDs, compared with Trunet and colleagues first study [21]
Hammerman and Kapeliovich, 2000 [14] Israel 36 months (July 1994 to June 1997) Prospective monocentre Teaching hospital (900 beds) CCU (9 beds) 2,559 Evaluate major cardiac iatrogenic disease as the cause of admission to the CCU
Lehmann and colleagues, 2005 [15] USA 12 months (November 1998 to November 1999) Prospective monocentre Four teaching hospitals Four surgical ICUs, three medical ICUs and one paediatric ICU 5,727 Identify the frequency and type of iatrogenic medical events requiring admission to the ICU. Assess the consequences of iatrogenic medical events for patients, and the incidence of disclosure of iatrogenic medical events to patients
Grenouillet-Delacre and colleagues, 2007 [16] France 6 months (May to October 2003) Prospective monocentre Teaching hospital Medical ICU 436 Assess the characteristics of life-threatening ADR in patients admitted to a medical ICU in order to identify associated risk factors that could facilitate early identification
Rivkin, 2007 [17] USA 19 weeks (December 2004 to May 2005) Prospective monocentre Teaching hospital (1,076 beds) Medical ICU (12 beds) 281 Determine frequency, severity and preventability of ADR leading to admission to a medical ICU
Schwake and colleagues, 2009 [18] Germany 12 months (January to December 2003) Prospective monocentre Teaching hospital (1,685 beds) Medical ICU (14 beds) 1,554 Determine the incidence of ICU admissions due to ADR and compare affected patients with patients admitted to the ICU for the treatment of deliberate self-poisoning using medical drugs
Mercier and colleagues, 2010 [19] France 6 months (November 1999 to April 2000) Prospective monocentre Teaching hospital Medical ICU (27 beds) 528 Determine the incidence, risk factors, severity and preventability of IEs as cause of ICU admission
Nazer and colleagues, 2013 [20] Jordan 5 months (August to December 2010) Prospective monocentre Teaching cancer centre (170 beds) Medico-surgical ICU (12 beds) 249 Describe the incidence, characteristics and cost of ADE that necessitate admission to the ICU in oncology patients
  1. ADE, adverse drug events; ADR, adverse drug reactions; CCU, coronary care unit; DII, drug-induced illness; ID, iatrogenic disease; IE, iatrogenic event; IGICE, Italian Group on Intensive Care Evaluation; ND, not documented. aNumber of patients hospitalised in the medical ICU department.