Table 3 Design and aims of the selected studies
From: A systematic review of adult admissions to ICUs related to adverse drug events
Study | Country | Study duration | Study design | Type of hospital | Type of ICU | Number of patients admitted during studied period | Aims of the study |
|---|---|---|---|---|---|---|---|
Trunet and colleagues, 1986 [10] | France | 33 months (August 1978 to April 1981) | Prospective monocentre | Teaching hospital | Multidisciplinary ICU | 1,651 | Determine cause and effect relationship between drugs and adverse event, severity of DII, role of underlying disease and potential preventability of DII |
IGICE, 1987 [11] | Italy | 6 months | Prospective (data collection on a given day each week) | ND | 27 general ICUs | 4,537 | Document aspects of ADR epidemiology in 27 general ICUs |
Nelson and Talbert, 1996 [12] | USA | 1 month (July to August 1993) | Prospective monocentre | Teaching hospital | Medical ICU, CCU and internal medicine service | 127a | Describe the frequency and pattern of drug-related morbidity that results in hospital admission and the extent to which these admissions are avoidable |
Darchy and colleagues, 1999 [13] | France | 12 months (January to December 1994) | Retrospective monocentre | General hospital (500 beds) | Medico-surgical ICU (15 beds), CCU (6 beds) | 623 | Determine whether aging of the general population and medical advances have altered the incidence, causes and consequences of severe IDs, compared with Trunet and colleagues first study [21] |
Hammerman and Kapeliovich, 2000 [14] | Israel | 36 months (July 1994 to June 1997) | Prospective monocentre | Teaching hospital (900 beds) | CCU (9 beds) | 2,559 | Evaluate major cardiac iatrogenic disease as the cause of admission to the CCU |
Lehmann and colleagues, 2005 [15] | USA | 12 months (November 1998 to November 1999) | Prospective monocentre | Four teaching hospitals | Four surgical ICUs, three medical ICUs and one paediatric ICU | 5,727 | Identify the frequency and type of iatrogenic medical events requiring admission to the ICU. Assess the consequences of iatrogenic medical events for patients, and the incidence of disclosure of iatrogenic medical events to patients |
Grenouillet-Delacre and colleagues, 2007 [16] | France | 6 months (May to October 2003) | Prospective monocentre | Teaching hospital | Medical ICU | 436 | Assess the characteristics of life-threatening ADR in patients admitted to a medical ICU in order to identify associated risk factors that could facilitate early identification |
Rivkin, 2007 [17] | USA | 19 weeks (December 2004 to May 2005) | Prospective monocentre | Teaching hospital (1,076 beds) | Medical ICU (12 beds) | 281 | Determine frequency, severity and preventability of ADR leading to admission to a medical ICU |
Schwake and colleagues, 2009 [18] | Germany | 12 months (January to December 2003) | Prospective monocentre | Teaching hospital (1,685 beds) | Medical ICU (14 beds) | 1,554 | Determine the incidence of ICU admissions due to ADR and compare affected patients with patients admitted to the ICU for the treatment of deliberate self-poisoning using medical drugs |
Mercier and colleagues, 2010 [19] | France | 6 months (November 1999 to April 2000) | Prospective monocentre | Teaching hospital | Medical ICU (27 beds) | 528 | Determine the incidence, risk factors, severity and preventability of IEs as cause of ICU admission |
Nazer and colleagues, 2013 [20] | Jordan | 5 months (August to December 2010) | Prospective monocentre | Teaching cancer centre (170 beds) | Medico-surgical ICU (12 beds) | 249 | Describe the incidence, characteristics and cost of ADE that necessitate admission to the ICU in oncology patients |