Table 1 Data items collected for the review

• Item

• First author^a

• Year of publication^a

• Country^a

• Study design^a

• Length of study^a

• Study population^a

• Inclusion and exclusion criteria^a

• Definitions of adverse drug events/adverse drug reactions/iatrogenic disease/iatrogenic event^a

• Definition and/or criteria for causality assessment method^a

• Definition of severity^a

• Definition of preventability^a

• Definition of predictability^a

• Statistical analyses^a

• Population characteristics^b

• Incidence of adverse drug events^b

• Drugs implied^b

• Causality results^b

• Items required for causality assessment methods^b

• Severity aspects^b

• Predictability^b

• Clinical features of adverse drug events^b

• Length of stay in the ICU^b

• Costs of hospitalisation in the ICU^b