TY - JOUR AU - Walley, Keith R. PY - 2014 DA - 2014/11/19 TI - Aging and the intramyocardial inflammatory response JO - Critical Care SP - 638 VL - 18 IS - 6 AB - The sepsis-induced intramyocardial inflammatory response results in decreased ventricular function and myocardial damage. Chemokines such as monocyte chemoattractant protein-1 causally contribute to retention of intramyocardial mononuclear leukocytes and subsequent ventricular dysfunction during endotoxemic shock in mice and, importantly, this effect is age dependent. It is therefore useful to consider where monocyte chemoattractant protein-1 fits in the complex pathway leading to ventricular dysfunction during sepsis, why this might be an age-dependent effect, and what this implies for care of older sepsis patients. SN - 1364-8535 UR - https://doi.org/10.1186/s13054-014-0638-2 DO - 10.1186/s13054-014-0638-2 ID - Walley2014 ER -