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Table 3 Performance of multivariable models for predicting 28-day mortality in septic patients

From: Diagnostic and prognostic value of neutrophil gelatinase-associated lipocalin, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinases-1 for sepsis in the Emergency Department: an observational study

 

Variable

Cutoff

Sensitivity, %

Specificity, %

PPV, %

NPV, %

28-day mortality

NGAL, ng/mL

236.62

71.80

77.10

79.50

74.50

 

MMP-9, ng/mL

95.29

55.30

83.80

43.80

89.20

 

TIMP-1, ng/mL

268.27

74.10

88.40

72.10

87.90

 

MMP-9/TIMP-1 ratio

0.401

47.70

77.80

20.90

92.40

 

PCT, ng/mL

4.27

64.30

84.10

65.20

84.10

  1. NGAL, neutrophil gelatinase-associated lipocalin; MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor of matrix metalloproteinase-1; PCT, procalcitonin;
  2. NPV, negative predictive value; PPV, positive predictive value.
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Critical Care

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