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Table 3 Vancomycin serum concentrations and pharmacokinetics in the ECMO group and in the control group

From: Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study

 

ECMO (n = 11)

Controls (n = 11)

At T1 (4 h), mg/L

51 (28 to 71)

45 (37 to 71)

At T2 (12 h), mg/L

23 (16 to 38)

29 (21 to 35)

At T3 (24 h), mg/L

20 (12 to 36)

23 (17 to 28)

Vd, L

99.3 (49.1 to 212.3)

92.3 (22.4 to 149.4)

Total CL, L/h

2.4 (1.7 to 4.9)

2.3 (1.8 to 3.6)

AUC0-24, mg*h/L

628 (537 to 840)

698 (622 to 753)

  1. ECMO, extracorporeal membrane oxygenation; Vd, drug median volume of distribution; CL, drug clearance; AUC0-24, area under the curve of the first 24 hrs of therapy.
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Critical Care

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