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Table 3 Association analysis of SNPs in TF and TFPI between the survivor and nonsurvivor groups

From: Genetic variation in the tissue factor gene is associated with clinical outcome in severe sepsis patients

Gene Survivor Nonsurvivor Allelic comparison Genotypic comparison
SNP P 1adj OR 1adj (95% CI) P 2adj OR 2adj (95% CI) P 1adj P 2adj
TF         
rs1324214    0.06 0.73 (0.53 to 1.01) 0.12 0.78 (0.56 to 1.16) 0.13 0.24
 CC 165 (55%) 103 (62.8%)       
 CT 118 (39.3%) 57 (34.8%)       
 TT 17 (5.7%) 4 (2.4%)       
 T 448 (74.7%) 263 (80.2%)       
 C 152 (25.3%) 65 (19.8%)       
rs762484    0.13 0.75 (0.51 to 1.09) 0.26 0.78 (0.82 to 1.07) 0.32 0.38
 TT 208 (68.6%) 124 (74.7%)       
 TC 85 (28%) 39 (23.5%)       
 CC 10 (3.3%) 3 (1.8%)       
 T 501 (82.7%) 287 (86.4%)       
 C 105 (17.3%) 45 (13.6%)       
rs696619    0.23 0.84 (0.63 to 1.12) 0.38 0.86 (0.73 to 1.09) 0.41 0.52
 AA 122 (40.4%) 75 (45.7%)       
 AG 156 (51.7%) 80 (48.8%)       
 GG 24 (7.9%) 9 (5.5%)       
 A 400 (66.2%) 230 (70.1%)       
 G 204 (33.8%) 98 (29.9%)       
rs3917615    0.00015 0.50 (0.35 to 0.72) 0.0018 0.69 (0.45 to 0.82) 0.00014 0.0017
 CC 167 (55.1%) 123 (74.5%)       
 CT 126 (41.6%) 39 (23.6%)       
 TT 10 (3.3%) 3 (1.8%)       
 C 460 (75.9%) 285 (86.4%)       
 T 146 (24.1%) 445 (13.6%)       
rs1361600    0.000049 0.48 (0.33 to 0.69) 0.00045 0.57 (0.41 to 0.74) 0.000024 0.00065
 AA 164 (53.6%) 124 (74.7%)       
 AG 130 (42.5%) 38 (22.9%)       
 GG 12 (3.9%) 4 (2.4%)       
 A 458 (74.8%) 286 (86.1%)       
 G 154 (25.2%) 46 (13.9%)       
rs958587    0.0001 0.50 (0.34 to 0.71) 0.0015 0.67 (0.43 to 0.79) 0.000094 0.0016
 CC 164 (53.9%) 122 (73.9%)       
 CT 130 (42.8%) 40 (24.2%)       
 TT 10 (3.3%) 3 (1.8%)       
 C  458 (75.3%) 284 (86%)       
 T 150 (24.7%) 46 (14%)       
rs3917643    0.62 1.84 (0.26 to 13.10) 0.78 1.48 (0.76 to 14.07) 0.62 0.78
 AA 304 (99.3%) 165 (98.8%)       
 AG 2 (0.7%) 2 (1.2%)       
 A 610 (99.7%) 332 (99.4%)       
 G 2 (0.3%) 2 (0.6%)       
rs145977586    1.00 0.92 (0.08 to 10.14) 0.95 0.93 (0.12 to 12.76) 1.00 0.95
 GG 304 (99.3%) 166 (99.4%)       
 GA 2 (0.7%) 1 (0.6%)       
 G 610 (99.7%) 333 (99.7%)       
 A 2 (0.3%) 1 (0.3%)       
TFPI         
rs3755248    0.75 0.94 (0.63 to 1.39) 0.62 0.84 (0.56 to 1.23) 0.13 0.11
 TT 222 (72.8%) 126 (76.4%)       
 TC 80 (26.2%) 34 (20.6%)       
 CC 3 (1%) 5 (3%)       
 T 524 (85.9%) 286 (86.7%)       
 C 86 (14.1%) 44 (13.3%)       
rs3213739    0.16 0.82 (0.62 to 1.08) 0.25 0.85 (0.72 to 1.04) 0.44 0.52
 GG 135 (44.7%) 84 (50.9%)       
 GT 84 (27.8%) 41 (24.8%)       
 TT 83 (27.5%) 40 (24.2%)       
 G 354 (58.6%) 209 (63.3%)       
 T 250 (41.4%) 121 (36.7%)       
rs7594359    0.18 0.78 (0.54 to 1.12) 0.12 0.71 (0.46 to 1.09) 0.23 0.18
 CC 197 (64.8%) 120 (71.9%)       
 CT 104 (34.2%) 45 (26.9%)       
 TT 3 (1%) 2 (1.2%)       
 C 498 (81.9%) 285 (85.3%)       
 T 110 (18.1%) 49 (14.7%)       
rs10931292    0.44 0.89 (0.67 to 1.19) 0.47 0.91 (0.81 to 1.13) 0.38 0.49
 TT 142 (47%) 87 (52.7%)       
 TC 122 (40.4%) 56 (33.9%)       
 CC 38 (12.6%) 22 (13.3%)       
 T 406 (67.2%) 230 (69.7%)       
 C 198 (32.8%) 100 (30.3%)       
rs8176441    0.87 1.03 (0.75 to 1.40) 0.95 0.92 (0.61 to 1.32) 0.06 0.17
 TT 185 (60.9%) 90 (55.6%)       
 TC 89 (29.3%) 63 (38.9%)       
 CC 30 (9.8%) 9 (5.5%)       
 T 459 (75.5%) 243 (75%)       
 C 149 (24.5%) 81 (25%)       
rs12613071    0.91 1.02 (0.76 to 1.37) 0.72 1.12 (0.83 to 1.58) 0.32 0.21
 TT 150 (50.2%) 86 (52.8%)       
 TC 124 (41.5%) 58 (35.6%)       
 CC 25 (8.4%) 19 (11.7%)       
 T 424 (70.9%) 230 (70.6%)       
 C 174 (29.1%) 96 (29.4%)       
rs10153820    0.20 1.21 (0.91 to 1.61) 0.45 1.15 (0.82 to 1.46) 0.25 0.52
 CC 161 (53.5%) 76 (45.8%)       
 CT 105 (34.9%) 70 (42.2%)       
 TT 35 (11.6%) 20 (12%)       
 C 427 (70.9%) 222 (66.9%)       
 T 175 (29.1%) 110 (33.1%)       
rs8176592    0.35 0.81 (0.52 to 1.26) 0.62 0.84 (0.71 to 1.19) 0.34 0.58
 TT 234 (77%) 133 (81.6%)       
 TC 68 (22.4%) 28 (17.2%)       
 CC 2 (0.6%) 2 (1.2%)       
 T 536 (88.2%) 294 (90.2%)       
 C 72 (11.8%) 32 (9.8%)       
rs2192824    0.48 0.89 (0.64 to 1.24) 0.52 0.91 (0.72 to 1.19) 0.38 0.41
 CC 190 (62.9%) 106 (63.9%)       
 CT 94 (31.1%) 55 (33.1%)       
 TT 18 (6%) 5 (3%)       
 C 474 (78.5%) 267 (80.4%)       
 T 130 (21.5%) 65 (19.6%)       
  1. Data presented as number (%) of subjects. P was determined using the chi-square test. Padj and ORadj came from multivariate logistic regression. P <0.0029 (0.05/17) was considered statistically significant after Bonferroni correction. CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism; TF, tissue factor; TFPI, tissue factor pathway inhibitor.