Skip to main content

Table 2 Association analysis of SNPs in TF and TFPI between the sepsis and severe sepsis groups

From: Genetic variation in the tissue factor gene is associated with clinical outcome in severe sepsis patients

Gene

Sepsis

Severe sepsis

Allelic comparison

Genotypic comparison

SNP

patients

patients

P 1adj

OR 1adj (95% CI)

P 2adj

OR 2adj (95% CI)

P 1adj

P 2adj

TF

        

rs1324214

  

0.13

0.86 (0.71 to 1.05)

0.22

0.89 (0.83 to 1.04)

0.09

0.14

 CC

270 (47.8%)

253 (54.2%)

      

 CT

270 (47.8%)

191 (40.9%)

      

 TT

25 (4.4%)

23 (4.9%)

      

 T

810 (71.7%)

697 (74.6%)

      

 C

320 (28.3%)

237 (25.4%)

      

rs762484

  

0.22

0.86 (0.69 to 1.09)

0.36

0.89 (0.74 to 1.07)

0.07

0.12

 TT

374 (66%)

330 (71%)

      

 TC

185 (32.6%)

124 (26.7%)

      

 CC

8 (1.4%)

11 (2.4%)

      

 T

933 (82.3%)

784 (84.3%)

      

 C

201 (17.7%)

146 (15.7%)

      

rs696619

  

0.31

0.91 (0.76 to 1.09)

0.46

0.93 (0.79 to 1.06)

0.14

0.26

 AA

228 (40.7%)

192 (41.5%)

      

 AG

271 (48.4%)

237 (51.2%)

      

 GG

61 (10.9%)

34 (7.3%)

      

 A

727 (64.9%)

621 (67.1%)

      

 G

393 (35.1%)

305 (32.9%)

      

rs3917615

  

0.87

0.98 (0.80 to 1.21)

0.92

0.98 (0.83 to 1.18)

0.07

0.16

 CC

344 (61.3%)

280 (59.5%)

      

 CT

189 (33.7%)

179 (38%)

      

 TT

28 (5%)

12 (2.5%)

      

 C

877 (78.2%)

739 (78.5%)

      

 T

245 (21.8%)

203 (21.5%)

      

rs1361600

  

0.53

0.94 (0.76 to 1.15)

0.72

0.95 (0.82 to 1.12)

0.07

0.16

 AA

342 (60%)

280 (59.6%)

      

 AG

198 (34.7%)

178 (37.9%)

      

 GG

30 (5.3%)

12 (2.6%)

      

 A

882 (77.4%)

738 (78.5%)

      

 G

258 (22.6%)

202 (21.5%)

      

rs958587

  

0.62

0.95 (0.77 to 1.17)

0.78

0.96 (0.84 to 1.14)

0.06

0.15

 CC

342 (60.4%)

279 (59.4%)

      

 CT

194 (34.3%)

178 (38.0%)

      

 TT

30 (5.3%)

12 (2.6%)

      

 C

878 (77.6%)

736 (78.5%)

      

 T

254 (22.4%)

202 (21.5%)

      

rs3917643

  

1.00

0.22 (0.25 to 6.05)

0.85

0.29 (0.32 to 5.26)

1.00

0.98

 AA

570 (99.5%)

468 (99.4%)

      

 AG

3 (0.5%)

3 (0.6%)

      

 A

1143 (99.7%)

939 (99.7%)

      

 G

3 (0.3%)

3 (0.3%)

      

rs145977586

  

1.00

0.22 (0.25 to 6.05)

0.85

0.29 (0.32 to 5.26)

1.00

0.98

 GG

570 (99.5%)

468 (99.4%)

      

 GA

3 (0.5%)

3 (0.6%)

      

 G

1143 (99.7%)

939 (99.7%)

      

 A

3 (0.3%)

3 (0.3%)

      

TFPI

        

rs3755248

  

0.75

0.96 (0.75 to 1.23)

0.67

0.87 (0.71 to 1.18)

0.71

0.62

 TT

412 (73%)

342 (73.4%)

      

 TC

141 (25%)

118 (25.3%)

      

 CC

11 (2%)

6 (12.9%)

      

 T

965 (85.5%)

802 (86.1%)

      

 C

163 (14.5%)

130 (13.9%)

      

rs3213739

  

0.46

1.07 (0.90 to 1.28)

0.32

1.15 (0.82 to 1.32)

0.79

0.56

 GG

270 (47.7%)

218 (46.4%)

      

 GT

156 (27.6%)

127 (27%)

      

 TT

140 (24.7%)

125 (26.6%)

      

 G

696 (61.5%)

563 (59.9%)

      

 T

436 (38.5%)

377 (40.1%)

      

rs7594359

  

0.93

0.99 (0.78 to 1.25)

0.94

0.94 (0.79 to 1.18)

0.12

0.17

 CC

389 (69.5%)

317 (68.2%)

      

 CT

156 (27.9%)

143 (30.8%)

      

 TT

15 (2.7%)

5 (1.1%)

      

 C

934 (83.4%)

777 (83.5%)

      

 T

186 (16.6%)

153 (16.5%)

      

rs10931292

  

0.92

0.99 (0.82 to 1.19)

0.82

0.78 (0.76 to 1.12)

0.14

0.12

 TT

255 (44.9%)

222 (47.9%)

      

 TC

253 (44.5%)

180 (38.9%)

      

 CC

60 (10.6%)

61 (13.2%)

      

 T

763 (67.2%)

624 (67.4%)

      

 C

373 (32.8%)

302 (32.6%)

      

rs8176441

  

0.93

0.99 (0.81 to 1.21)

0.82

0.76 (0.56 to 1.48)

0.10

0.23

 TT

300 (52.9%)

259 (55.7%)

      

 TC

237 (41.8%)

170 (36.6%)

      

 CC

30 (5.3%)

36 (7.7%)

      

 T

837 (73.8%)

688 (74%)

      

 C

297 (26.2%)

242 (26%)

      

rs12613071

  

0.84

1.02 (0.84 to 1.23)

0.75

1.24 (0.86 to 1.38)

0.98

0.95

 TT

288 (50.9%)

233 (50.2%)

      

 TC

224 (39.6%)

186 (40.1%)

      

 CC

54 (9.5%)

45 (9.7%)

      

 T

800 (70.7%)

652 (70.3%)

      

 C

332 (29.3%)

276 (29.7%)

      

rs10153820

  

0.58

0.95 (0.79 to 1.14)

0.62

0.98 (0.81 to 1.12)

0.15

0.36

 GG

254 (45.3%)

230 (49.4%)

      

 GA

251 (44.7%)

181 (38.8%)

      

 AA

56 (10%)

55 (11.8%)

      

 G

759 (67.6%)

641 (68.8%)

      

 A

363 (32.4%)

291 (31.2%)

      

rs8176592

  

0.12

1.24 (0.94 to 1.63)

0.36

1.16 (0.97 to 1.58)

0.31

0.45

 TT

461 (80.9%)

363 (77.1%)

      

 TC

102 (17.9%)

100 (21.2%)

      

 CC

7 (1.2%)

8 (1.7%)

      

 T

1024 (89.8%)

826 (87.7%)

      

 C

116 (10.2%)

116 (12.3%)

      

rs2192824

  

0.79

1.03 (0.83 to 1.27)

0.65

1.13 (0.92 to 1.46)

0.76

0.68

 CC

354 (62.7%)

292 (62.7%)

      

 CT

185 (32.7%)

148 (31.8%)

      

 TT

26 (4.6%)

26 (5.6%)

      

 C

893 (79%)

732 (78.5%)

      

 T

237 (21%)

200 (21.5%)

      
  1. Data presented as number (%) of subjects. P was determined using the chi-square test. Padj and ORadj came from multivariate logistic regression. P <0.0029 (0.05/17) was considered statistically significant after Bonferroni correction. CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism; TF, tissue factor; TFPI, tissue factor pathway inhibitor.
Back to article page

Critical Care

ISSN: 1364-8535