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Table 2 Association analysis of SNPs in TF and TFPI between the sepsis and severe sepsis groups

From: Genetic variation in the tissue factor gene is associated with clinical outcome in severe sepsis patients

Gene Sepsis Severe sepsis Allelic comparison Genotypic comparison
SNP patients patients P 1adj OR 1adj (95% CI) P 2adj OR 2adj (95% CI) P 1adj P 2adj
TF         
rs1324214    0.13 0.86 (0.71 to 1.05) 0.22 0.89 (0.83 to 1.04) 0.09 0.14
 CC 270 (47.8%) 253 (54.2%)       
 CT 270 (47.8%) 191 (40.9%)       
 TT 25 (4.4%) 23 (4.9%)       
 T 810 (71.7%) 697 (74.6%)       
 C 320 (28.3%) 237 (25.4%)       
rs762484    0.22 0.86 (0.69 to 1.09) 0.36 0.89 (0.74 to 1.07) 0.07 0.12
 TT 374 (66%) 330 (71%)       
 TC 185 (32.6%) 124 (26.7%)       
 CC 8 (1.4%) 11 (2.4%)       
 T 933 (82.3%) 784 (84.3%)       
 C 201 (17.7%) 146 (15.7%)       
rs696619    0.31 0.91 (0.76 to 1.09) 0.46 0.93 (0.79 to 1.06) 0.14 0.26
 AA 228 (40.7%) 192 (41.5%)       
 AG 271 (48.4%) 237 (51.2%)       
 GG 61 (10.9%) 34 (7.3%)       
 A 727 (64.9%) 621 (67.1%)       
 G 393 (35.1%) 305 (32.9%)       
rs3917615    0.87 0.98 (0.80 to 1.21) 0.92 0.98 (0.83 to 1.18) 0.07 0.16
 CC 344 (61.3%) 280 (59.5%)       
 CT 189 (33.7%) 179 (38%)       
 TT 28 (5%) 12 (2.5%)       
 C 877 (78.2%) 739 (78.5%)       
 T 245 (21.8%) 203 (21.5%)       
rs1361600    0.53 0.94 (0.76 to 1.15) 0.72 0.95 (0.82 to 1.12) 0.07 0.16
 AA 342 (60%) 280 (59.6%)       
 AG 198 (34.7%) 178 (37.9%)       
 GG 30 (5.3%) 12 (2.6%)       
 A 882 (77.4%) 738 (78.5%)       
 G 258 (22.6%) 202 (21.5%)       
rs958587    0.62 0.95 (0.77 to 1.17) 0.78 0.96 (0.84 to 1.14) 0.06 0.15
 CC 342 (60.4%) 279 (59.4%)       
 CT 194 (34.3%) 178 (38.0%)       
 TT 30 (5.3%) 12 (2.6%)       
 C 878 (77.6%) 736 (78.5%)       
 T 254 (22.4%) 202 (21.5%)       
rs3917643    1.00 0.22 (0.25 to 6.05) 0.85 0.29 (0.32 to 5.26) 1.00 0.98
 AA 570 (99.5%) 468 (99.4%)       
 AG 3 (0.5%) 3 (0.6%)       
 A 1143 (99.7%) 939 (99.7%)       
 G 3 (0.3%) 3 (0.3%)       
rs145977586    1.00 0.22 (0.25 to 6.05) 0.85 0.29 (0.32 to 5.26) 1.00 0.98
 GG 570 (99.5%) 468 (99.4%)       
 GA 3 (0.5%) 3 (0.6%)       
 G 1143 (99.7%) 939 (99.7%)       
 A 3 (0.3%) 3 (0.3%)       
TFPI         
rs3755248    0.75 0.96 (0.75 to 1.23) 0.67 0.87 (0.71 to 1.18) 0.71 0.62
 TT 412 (73%) 342 (73.4%)       
 TC 141 (25%) 118 (25.3%)       
 CC 11 (2%) 6 (12.9%)       
 T 965 (85.5%) 802 (86.1%)       
 C 163 (14.5%) 130 (13.9%)       
rs3213739    0.46 1.07 (0.90 to 1.28) 0.32 1.15 (0.82 to 1.32) 0.79 0.56
 GG 270 (47.7%) 218 (46.4%)       
 GT 156 (27.6%) 127 (27%)       
 TT 140 (24.7%) 125 (26.6%)       
 G 696 (61.5%) 563 (59.9%)       
 T 436 (38.5%) 377 (40.1%)       
rs7594359    0.93 0.99 (0.78 to 1.25) 0.94 0.94 (0.79 to 1.18) 0.12 0.17
 CC 389 (69.5%) 317 (68.2%)       
 CT 156 (27.9%) 143 (30.8%)       
 TT 15 (2.7%) 5 (1.1%)       
 C 934 (83.4%) 777 (83.5%)       
 T 186 (16.6%) 153 (16.5%)       
rs10931292    0.92 0.99 (0.82 to 1.19) 0.82 0.78 (0.76 to 1.12) 0.14 0.12
 TT 255 (44.9%) 222 (47.9%)       
 TC 253 (44.5%) 180 (38.9%)       
 CC 60 (10.6%) 61 (13.2%)       
 T 763 (67.2%) 624 (67.4%)       
 C 373 (32.8%) 302 (32.6%)       
rs8176441    0.93 0.99 (0.81 to 1.21) 0.82 0.76 (0.56 to 1.48) 0.10 0.23
 TT 300 (52.9%) 259 (55.7%)       
 TC 237 (41.8%) 170 (36.6%)       
 CC 30 (5.3%) 36 (7.7%)       
 T 837 (73.8%) 688 (74%)       
 C 297 (26.2%) 242 (26%)       
rs12613071    0.84 1.02 (0.84 to 1.23) 0.75 1.24 (0.86 to 1.38) 0.98 0.95
 TT 288 (50.9%) 233 (50.2%)       
 TC 224 (39.6%) 186 (40.1%)       
 CC 54 (9.5%) 45 (9.7%)       
 T 800 (70.7%) 652 (70.3%)       
 C 332 (29.3%) 276 (29.7%)       
rs10153820    0.58 0.95 (0.79 to 1.14) 0.62 0.98 (0.81 to 1.12) 0.15 0.36
 GG 254 (45.3%) 230 (49.4%)       
 GA 251 (44.7%) 181 (38.8%)       
 AA 56 (10%) 55 (11.8%)       
 G 759 (67.6%) 641 (68.8%)       
 A 363 (32.4%) 291 (31.2%)       
rs8176592    0.12 1.24 (0.94 to 1.63) 0.36 1.16 (0.97 to 1.58) 0.31 0.45
 TT 461 (80.9%) 363 (77.1%)       
 TC 102 (17.9%) 100 (21.2%)       
 CC 7 (1.2%) 8 (1.7%)       
 T 1024 (89.8%) 826 (87.7%)       
 C 116 (10.2%) 116 (12.3%)       
rs2192824    0.79 1.03 (0.83 to 1.27) 0.65 1.13 (0.92 to 1.46) 0.76 0.68
 CC 354 (62.7%) 292 (62.7%)       
 CT 185 (32.7%) 148 (31.8%)       
 TT 26 (4.6%) 26 (5.6%)       
 C 893 (79%) 732 (78.5%)       
 T 237 (21%) 200 (21.5%)       
  1. Data presented as number (%) of subjects. P was determined using the chi-square test. Padj and ORadj came from multivariate logistic regression. P <0.0029 (0.05/17) was considered statistically significant after Bonferroni correction. CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism; TF, tissue factor; TFPI, tissue factor pathway inhibitor.