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Table 1 Demographic and clinical characteristics of the study subjects

From: Genetic variation in the tissue factor gene is associated with clinical outcome in severe sepsis patients

  Sepsis patients Severe sepsis patients P value a Survivors Nonsurvivors P value b
Number 577 476 NA 308 168 NA
Age 62.6 ± 11.2 66.1 ± 11.5 0.07 62.6 ± 10.8 68.9 ± 13.7 0.04
Sex (male/female) 334/243 275/201 0.56 180/128 98/70 0.98
APACHE II score 10.4 ± 3.3 18.7 ± 4.8 0.007 14.6 ± 2.8 26.2 ± 7.1 0.008
Diabetes 50 (8.7%) 51 (10.7%) 0.26 33 (10.7%) 18 (10.7%) 1.00
Chronic liver disease 11 (1.9%) 17 (3.6%) 0.10 9 (2.9%) 8 (4.8%) 0.30
Chronic renal failure 18 (3.1%) 20 (4.2%) 0.35 12 (3.9%) 8 (4.8%) 0.65
Congestive heart failure 25 (4.3%) 32 (6.7%) 0.09 20 (6.5%) 12 (7.1%) 0.79
Chronic pulmonary disease 35 (6.1%) 42 (8.8%) 0.09 25 (8.1%) 17 (10.1%) 0.46
SOFA score 1.4 ± 0.3 8.1 ± 1.7 <0.001 6.8 ± 1.8 10.5 ± 1.8 0.01
LOS (days) 8.5 ± 2.6 15.3 ± 8.6 0.006 13.5 ± 7.3 15.1 ± 8.9 0.02
Infection insult       
Lung 380 (65.9%) 312 (65.5%) 0.92 206 (66.9%) 106 (63.1%) 0.41
Abdomen 151 (26.2%) 119 (25.0%) 0.67 73 (23.7%) 46 (27.4%) 0.38
Bloodstream 13 (2.3%) 17 (3.6%) 0.20 8(2.6%) 9 (5.4%) 0.12
UTI 11 (1.9%) 12 (2.5%) 0.50 9 (2.9%) 3 (1.8%) 0.45
Others 22 (3.8%) 16 (3.4%) 0.70 12 (3.9%) 4 (2.4%) 0.38
Microbiology positivec 225 (39.0%) 195 (41.0%) 0.52 114 (37.0%) 76 (45.2%) 0.08
Gram-positive 96 (42.7%) 75 (38.5%) 0.38 47 (41.2%) 27 (35.5%) 0.43
Gram-negative 98 (43.6%) 81 (41.5%) 0.68 47 (41.2%) 31 (40.8%) 0.95
Fungi 15 (6.7%) 18 (9.2%) 0.33 10 (8.8%) 8 (10.5%) 0.69
Mixed 16 (7.1%) 21 (10.8%) 0.19 10 (8.8%) 10 (13.2%) 0.34
  1. Data presented as mean ± standard deviation or number (%). APACHE, Acute Physiology and Chronic Health Evaluation; LOS, length of ICU stay; NA, not applicable; SOFA, Sequential Organ Failure Assessment; UTI, urinary tract infection. aSepsis group versus severe sepsis group. bSurvivor group versus nonsurvivor group. cIncluded relevant cultures from tissue sites, sputum, blood, urine, pleural and peritoneal fluid.