Genetic variation in the tissue factor gene is associated with clinical outcome in severe sepsis patients

Table 1 Demographic and clinical characteristics of the study subjects

	Sepsis patients	Severe sepsis patients	P value ^a	Survivors	Nonsurvivors	P value ^b
Number	577	476	NA	308	168	NA
Age	62.6 ± 11.2	66.1 ± 11.5	0.07	62.6 ± 10.8	68.9 ± 13.7	0.04
Sex (male/female)	334/243	275/201	0.56	180/128	98/70	0.98
APACHE II score	10.4 ± 3.3	18.7 ± 4.8	0.007	14.6 ± 2.8	26.2 ± 7.1	0.008
Diabetes	50 (8.7%)	51 (10.7%)	0.26	33 (10.7%)	18 (10.7%)	1.00
Chronic liver disease	11 (1.9%)	17 (3.6%)	0.10	9 (2.9%)	8 (4.8%)	0.30
Chronic renal failure	18 (3.1%)	20 (4.2%)	0.35	12 (3.9%)	8 (4.8%)	0.65
Congestive heart failure	25 (4.3%)	32 (6.7%)	0.09	20 (6.5%)	12 (7.1%)	0.79
Chronic pulmonary disease	35 (6.1%)	42 (8.8%)	0.09	25 (8.1%)	17 (10.1%)	0.46
SOFA score	1.4 ± 0.3	8.1 ± 1.7	<0.001	6.8 ± 1.8	10.5 ± 1.8	0.01
LOS (days)	8.5 ± 2.6	15.3 ± 8.6	0.006	13.5 ± 7.3	15.1 ± 8.9	0.02
Infection insult
Lung	380 (65.9%)	312 (65.5%)	0.92	206 (66.9%)	106 (63.1%)	0.41
Abdomen	151 (26.2%)	119 (25.0%)	0.67	73 (23.7%)	46 (27.4%)	0.38
Bloodstream	13 (2.3%)	17 (3.6%)	0.20	8(2.6%)	9 (5.4%)	0.12
UTI	11 (1.9%)	12 (2.5%)	0.50	9 (2.9%)	3 (1.8%)	0.45
Others	22 (3.8%)	16 (3.4%)	0.70	12 (3.9%)	4 (2.4%)	0.38
Microbiology positive^c	225 (39.0%)	195 (41.0%)	0.52	114 (37.0%)	76 (45.2%)	0.08
Gram-positive	96 (42.7%)	75 (38.5%)	0.38	47 (41.2%)	27 (35.5%)	0.43
Gram-negative	98 (43.6%)	81 (41.5%)	0.68	47 (41.2%)	31 (40.8%)	0.95
Fungi	15 (6.7%)	18 (9.2%)	0.33	10 (8.8%)	8 (10.5%)	0.69
Mixed	16 (7.1%)	21 (10.8%)	0.19	10 (8.8%)	10 (13.2%)	0.34

Data presented as mean ± standard deviation or number (%). APACHE, Acute Physiology and Chronic Health Evaluation; LOS, length of ICU stay; NA, not applicable; SOFA, Sequential Organ Failure Assessment; UTI, urinary tract infection. ^aSepsis group versus severe sepsis group. ^bSurvivor group versus nonsurvivor group. ^cIncluded relevant cultures from tissue sites, sputum, blood, urine, pleural and peritoneal fluid.

ISSN: 1364-8535