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Table 2 Characteristics of liver transplant patients grouped by acute kidney injury according to the RIFLE classification

From: Chloride-liberal fluids are associated with acute kidney injury after liver transplantation

 

No AKI (n = 101)

AKI (n =57)

P value

Age , years

51 ± 14.2

54 ± 11.3

0.13

BMI

26.4 ± 6

27.7 ± 6.6

0.19

Pretransplant creatinine , micromol/L

76.2 ± 40.2

110.8 ± 72.6

0.001

Pretransplant MELD score

19.2 ± 5.4

21.8 ± 9.1

0.001

Volume of chloride-liberal fluids , liters (IQR)

   

Operating room

4.7 (5.7)

6 (6.8)

0.23

24 hours

2.1 (1.2)

3.8 (2.7)

<0.001

48 hours

0.64 (1.06)

1.7 (1.5)

0.007

72 hours

0.35 (0.65)

1.07 (0.87)

0.55

Volume of chloride-restrictive fluids , liters (IQR)

   

Operating room

2 (2)

2 (1.2)

0.46

24 hours

1.9 (1.28)

1.8 (1.4)

0.32

48 hours

2.0 (0.76)

1.9 (1.6)

0.86

72 hours

1.3 (1.0)

1.6 (1.1)

0.67

Volume of colloids , liters (IQR)

   

Operating room

1.5 (1)

2.1 (2.5)

0.013

24 hours posttransplant

1.2 (1.03)

1.9 (1.4)

0.001

48 hours posttransplant

0.45 (0.85)

0.95 (0.71)

0.016

72 hours posttransplant

0.35 (0.65)

1.0 (0.87)

0.05

Volume of packed RBC transfusions , liters (IQR)

   

Operating room

1.5 (1.2)

2.2 (1.9)

0.022

24 hours

0.76 (0.44)

1.14 (5.8)

0.19

48 hours

0.53 (0.38)

0.72 (0.53)

0.08

72 hours

0.38 (0.71)

0.38 (0.06)

0.89

Volume of blood products transfused , liters (IQR)

   

Operating room

3.2 (2.3)

3.8 (3.2)

0.17

24 hours

0.95 (2.1)

2.1 (4.8)

0.14

48 hours posttransplant

0.72 (0.53)

0.97 (1.2)

0.63

72 hours posttransplant

0.63 (1.5)

0.51 (0.32)

0.78

Volume of crystalloids infused , liters (IQR)

   

Operating room

6 (5.6)

6 (6)

0.8

24 hours

2.5 (1.3)

3.1 (1.9)

0.15

48 hours

2.1 (0.72)

2.4 (1.4)

0.22

72 hours

1.6 (0.96)

1.7 (1.1)

0.30

Fluid balance , liters (IQR)

   

Operating room

6.4 (4.7)

6.7 (5.4)

0.76

24 hours

2.9 (2.6)

3.7 (4.8)

0.09

48 hours

1.6 (1.5)

1.7 (2.4)

0.06

72 hours

0.947 (2.07)

0.623 (1.54)

0.93

Serum lactate , mmol/L

   

Day 1

4.2 ± 2.9

4.8 ± 3.9

0.26

Day 2

1.8 ± 1.1

2.1 ± 1.6

0.09

Day 3

1.4 ± 0.5

1.9 ± 0.3

0.046

Serum sodium , mmol/L

   

Day 1

146 ± 5.2

146.5 ± 5.0

0.57

Day 2

143 ± 5.7

145 ± 3

0.016

Day 3

144 ± 2.3

146 ± 2.6

0.002

Serum chloride , mmol/L

   

Day 1

114 ± 5.7

113 ± 5.9

0.76

Day 2

112 ± 4.4

114 ± 7.2

0.01

Day 3

110 ± 4.6

111 ± 4.8

0.18

Vasopressor requirement

   

At admission

73 (72%)

47 (82.5%)

0.25

Day 1

3 (3%)

1 (1.8%)

0.64

Day 2

15 (14.8%)

21 (36.8%)

0.002

Day 3

4 (4%)

8 (14%)

0.056

Days on mechanical ventilation

2.3 ± 3.6

6 ± 7.1

0.001

Length of ICU stay after transplant

5.5 ± 4.7

13.4 ± 19

0.003

  1. AKI, acute kidney injury; BMI, body mass index; ICU, intensive care unit; IQR, interquartile range; MELD, model for end-stage liver disease; RIFLE, risk, injury, failure, loss, end-stage renal failure.