From: Chloride-liberal fluids are associated with acute kidney injury after liver transplantation
 | No AKI (n = 101) | AKI (n =57) | P value |
---|---|---|---|
Age , years | 51 ± 14.2 | 54 ± 11.3 | 0.13 |
BMI | 26.4 ± 6 | 27.7 ± 6.6 | 0.19 |
Pretransplant creatinine , micromol/L | 76.2 ± 40.2 | 110.8 ± 72.6 | 0.001 |
Pretransplant MELD score | 19.2 ± 5.4 | 21.8 ± 9.1 | 0.001 |
Volume of chloride-liberal fluids , liters (IQR) | Â | Â | Â |
Operating room | 4.7 (5.7) | 6 (6.8) | 0.23 |
24 hours | 2.1 (1.2) | 3.8 (2.7) | <0.001 |
48 hours | 0.64 (1.06) | 1.7 (1.5) | 0.007 |
72 hours | 0.35 (0.65) | 1.07 (0.87) | 0.55 |
Volume of chloride-restrictive fluids , liters (IQR) | Â | Â | Â |
Operating room | 2 (2) | 2 (1.2) | 0.46 |
24 hours | 1.9 (1.28) | 1.8 (1.4) | 0.32 |
48 hours | 2.0 (0.76) | 1.9 (1.6) | 0.86 |
72 hours | 1.3 (1.0) | 1.6 (1.1) | 0.67 |
Volume of colloids , liters (IQR) | Â | Â | Â |
Operating room | 1.5 (1) | 2.1 (2.5) | 0.013 |
24 hours posttransplant | 1.2 (1.03) | 1.9 (1.4) | 0.001 |
48 hours posttransplant | 0.45 (0.85) | 0.95 (0.71) | 0.016 |
72 hours posttransplant | 0.35 (0.65) | 1.0 (0.87) | 0.05 |
Volume of packed RBC transfusions , liters (IQR) | Â | Â | Â |
Operating room | 1.5 (1.2) | 2.2 (1.9) | 0.022 |
24 hours | 0.76 (0.44) | 1.14 (5.8) | 0.19 |
48 hours | 0.53 (0.38) | 0.72 (0.53) | 0.08 |
72 hours | 0.38 (0.71) | 0.38 (0.06) | 0.89 |
Volume of blood products transfused , liters (IQR) | Â | Â | Â |
Operating room | 3.2 (2.3) | 3.8 (3.2) | 0.17 |
24 hours | 0.95 (2.1) | 2.1 (4.8) | 0.14 |
48 hours posttransplant | 0.72 (0.53) | 0.97 (1.2) | 0.63 |
72 hours posttransplant | 0.63 (1.5) | 0.51 (0.32) | 0.78 |
Volume of crystalloids infused , liters (IQR) | Â | Â | Â |
Operating room | 6 (5.6) | 6 (6) | 0.8 |
24 hours | 2.5 (1.3) | 3.1 (1.9) | 0.15 |
48 hours | 2.1 (0.72) | 2.4 (1.4) | 0.22 |
72 hours | 1.6 (0.96) | 1.7 (1.1) | 0.30 |
Fluid balance , liters (IQR) | Â | Â | Â |
Operating room | 6.4 (4.7) | 6.7 (5.4) | 0.76 |
24 hours | 2.9 (2.6) | 3.7 (4.8) | 0.09 |
48 hours | 1.6 (1.5) | 1.7 (2.4) | 0.06 |
72 hours | 0.947 (2.07) | 0.623 (1.54) | 0.93 |
Serum lactate , mmol/L | Â | Â | Â |
Day 1 | 4.2 ± 2.9 | 4.8 ± 3.9 | 0.26 |
Day 2 | 1.8 ± 1.1 | 2.1 ± 1.6 | 0.09 |
Day 3 | 1.4 ± 0.5 | 1.9 ± 0.3 | 0.046 |
Serum sodium , mmol/L | Â | Â | Â |
Day 1 | 146 ± 5.2 | 146.5 ± 5.0 | 0.57 |
Day 2 | 143 ± 5.7 | 145 ± 3 | 0.016 |
Day 3 | 144 ± 2.3 | 146 ± 2.6 | 0.002 |
Serum chloride , mmol/L | Â | Â | Â |
Day 1 | 114 ± 5.7 | 113 ± 5.9 | 0.76 |
Day 2 | 112 ± 4.4 | 114 ± 7.2 | 0.01 |
Day 3 | 110 ± 4.6 | 111 ± 4.8 | 0.18 |
Vasopressor requirement | Â | Â | Â |
At admission | 73 (72%) | 47 (82.5%) | 0.25 |
Day 1 | 3 (3%) | 1 (1.8%) | 0.64 |
Day 2 | 15 (14.8%) | 21 (36.8%) | 0.002 |
Day 3 | 4 (4%) | 8 (14%) | 0.056 |
Days on mechanical ventilation | 2.3 ± 3.6 | 6 ± 7.1 | 0.001 |
Length of ICU stay after transplant | 5.5 ± 4.7 | 13.4 ± 19 | 0.003 |