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Table 4 Final multiple logistic regression model for mortality in subgroup of patients with cumulative fluid balance and weight available

From: Fluid balance, intradialytic hypotension, and outcomes in critically ill patients undergoing renal replacement therapy: a cohort study

Variable Unadjusted OR P value Adjusted OR P value
(95% CI) (95% CI)
Mean daily fluid balance (per 1000 mL positive) 1.67 (1.40-1.99) <0.001 1.53 (1.25-1.87) <0.001
Intradialytic hypotension (per 10% increase in number of days) 1.31 (1.21-1.43) <0.001 1.18 (1.06-1.31) 0.002
Fluid overload >10% vs. ≤10% 2.27 (1.42-3.64) 0.006 2.03 (1.12-3.68) 0.02
Age (per 5-year increase) 1.04 (0.98-1.12) 0.21 1.11 (1.01-1.22) 0.02
Male sex 0.94 (0.59-1.48) 0.78 1.14 (0.64-2.04) 0.66
Charlson comorbidity index 1.09 (0.98-1.21) 0.10 1.21 (1.05-1.39) 0.01
Abdominal aortic aneurysm repair 0.55 (0.23-1.34) 0.19 0.65 (0.22, 1.96) 0.44
Primary renal diagnosis 0.55 (0.27-1.13) 0.10 1.31 (0.53-3.26) 0.56
Baseline creatinine (per 10 μmol/L increase) 0.97 (0.96-0.99) 0.003 0.99 (0.97-1.01) 0.24
Maximum SOFA on days 1-7 1.24 (1.16-1.32) <0.001 1.15 (1.05-1.26) 0.002
Any vasopressors on days 1-7 3.37 (2.07-5.46) <0.001 1.52 (0.78-2.95) 0.22
Initial RRT modality
  CRRT vs. IHD 3.11 (1.89, 5.11) <0.001 0.77 (0.39-1.52) 0.45
  sLED vs. IHD 1.18 (0.56, 2.51) 0.66 0.51 (0.20-1.32) 0.16
  1. The final model had 308 patients and 168 deaths; it did not demonstrate lack of goodness of fit (Hosmer Lemeshow P = 0.62). There was no evidence of interaction between mean daily fluid balance and fluid overload (P = 0.72); we therefore report the results of the model with no interaction term. CI, confidence interval; CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis; OR, odds ratio; RRT, renal replacement therapy; SLED, sustained low-efficiency dialysis; SOFA, sequential organ failure assessment score.