Fluid balance, intradialytic hypotension, and outcomes in critically ill patients undergoing renal replacement therapy: a cohort study

Table 4 Final multiple logistic regression model for mortality in subgroup of patients with cumulative fluid balance and weight available

Variable	Unadjusted OR	P value	Adjusted OR	P value
Variable	(95% CI)	P value	(95% CI)	P value
Mean daily fluid balance (per 1000 mL positive)	1.67 (1.40-1.99)	<0.001	1.53 (1.25-1.87)	<0.001
Intradialytic hypotension (per 10% increase in number of days)	1.31 (1.21-1.43)	<0.001	1.18 (1.06-1.31)	0.002
Fluid overload >10% vs. ≤10%	2.27 (1.42-3.64)	0.006	2.03 (1.12-3.68)	0.02
Age (per 5-year increase)	1.04 (0.98-1.12)	0.21	1.11 (1.01-1.22)	0.02
Male sex	0.94 (0.59-1.48)	0.78	1.14 (0.64-2.04)	0.66
Charlson comorbidity index	1.09 (0.98-1.21)	0.10	1.21 (1.05-1.39)	0.01
Abdominal aortic aneurysm repair	0.55 (0.23-1.34)	0.19	0.65 (0.22, 1.96)	0.44
Primary renal diagnosis	0.55 (0.27-1.13)	0.10	1.31 (0.53-3.26)	0.56
Baseline creatinine (per 10 μmol/L increase)	0.97 (0.96-0.99)	0.003	0.99 (0.97-1.01)	0.24
Maximum SOFA on days 1-7	1.24 (1.16-1.32)	<0.001	1.15 (1.05-1.26)	0.002
Any vasopressors on days 1-7	3.37 (2.07-5.46)	<0.001	1.52 (0.78-2.95)	0.22
Initial RRT modality
CRRT vs. IHD	3.11 (1.89, 5.11)	<0.001	0.77 (0.39-1.52)	0.45
sLED vs. IHD	1.18 (0.56, 2.51)	0.66	0.51 (0.20-1.32)	0.16

The final model had 308 patients and 168 deaths; it did not demonstrate lack of goodness of fit (Hosmer Lemeshow P = 0.62). There was no evidence of interaction between mean daily fluid balance and fluid overload (P = 0.72); we therefore report the results of the model with no interaction term. CI, confidence interval; CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis; OR, odds ratio; RRT, renal replacement therapy; SLED, sustained low-efficiency dialysis; SOFA, sequential organ failure assessment score.

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