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Table 4 Final multiple logistic regression model for mortality in subgroup of patients with cumulative fluid balance and weight available

From: Fluid balance, intradialytic hypotension, and outcomes in critically ill patients undergoing renal replacement therapy: a cohort study

Variable

Unadjusted OR

P value

Adjusted OR

P value

(95% CI)

(95% CI)

Mean daily fluid balance (per 1000 mL positive)

1.67 (1.40-1.99)

<0.001

1.53 (1.25-1.87)

<0.001

Intradialytic hypotension (per 10% increase in number of days)

1.31 (1.21-1.43)

<0.001

1.18 (1.06-1.31)

0.002

Fluid overload >10% vs. ≤10%

2.27 (1.42-3.64)

0.006

2.03 (1.12-3.68)

0.02

Age (per 5-year increase)

1.04 (0.98-1.12)

0.21

1.11 (1.01-1.22)

0.02

Male sex

0.94 (0.59-1.48)

0.78

1.14 (0.64-2.04)

0.66

Charlson comorbidity index

1.09 (0.98-1.21)

0.10

1.21 (1.05-1.39)

0.01

Abdominal aortic aneurysm repair

0.55 (0.23-1.34)

0.19

0.65 (0.22, 1.96)

0.44

Primary renal diagnosis

0.55 (0.27-1.13)

0.10

1.31 (0.53-3.26)

0.56

Baseline creatinine (per 10 μmol/L increase)

0.97 (0.96-0.99)

0.003

0.99 (0.97-1.01)

0.24

Maximum SOFA on days 1-7

1.24 (1.16-1.32)

<0.001

1.15 (1.05-1.26)

0.002

Any vasopressors on days 1-7

3.37 (2.07-5.46)

<0.001

1.52 (0.78-2.95)

0.22

Initial RRT modality

  CRRT vs. IHD

3.11 (1.89, 5.11)

<0.001

0.77 (0.39-1.52)

0.45

  sLED vs. IHD

1.18 (0.56, 2.51)

0.66

0.51 (0.20-1.32)

0.16

  1. The final model had 308 patients and 168 deaths; it did not demonstrate lack of goodness of fit (Hosmer Lemeshow P = 0.62). There was no evidence of interaction between mean daily fluid balance and fluid overload (P = 0.72); we therefore report the results of the model with no interaction term. CI, confidence interval; CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis; OR, odds ratio; RRT, renal replacement therapy; SLED, sustained low-efficiency dialysis; SOFA, sequential organ failure assessment score.