Fluid balance, intradialytic hypotension, and outcomes in critically ill patients undergoing renal replacement therapy: a cohort study

Table 3 Final multiple logistic regression model for RRT dependence at hospital discharge in survivors.

Variable	Unadjusted OR	P value	Adjusted OR	P value
Variable	(95% CI)	P value	(95% CI)	P value
Mean daily fluid balance (per 1000 mL positive)	0.91 (0.74-1.12)	0.36	0.93 (0.75-1.16)	0.54
Intradialytic hypotension (per 10% increase in number of days)	1.01 (0.92-1.11)	0.86	1.02 (0.92-1.13)	0.69
Male sex	1.05 (0.58-1.91)	0.87	1.20 (0.62-2.31)	0.59
Congestive heart failure	2.60 (1.30-5.19)	0.007	3.13 (1.46-6.74)	0.003
Medical (versus surgical) diagnosis	1.84 (1.02-3.32)	0.04	1.75 (0.88-3.47)	0.11
Primary renal diagnosis	2.02 (0.97-4.23)	0.06	1.72 (0.75-3.94)	0.20
Baseline creatinine (per 10 μmol/L increase)	1.01 (0.999-1.02)	0.07	1.01 (0.995-1.02)	0.23
Maximum SOFA on days 1-7	0.94 (0.87-1.01)	0.10	0.98 (0.89-1.07)	0.65
Initial RRT modality
CRRT vs. IHD	0.52 (0.26-1.04)	0.06	0.72 (0.31-1.65)	0.43
sLED vs. IHD	1.18 (0.51-2.75)	0.70	1.51 (0.60-3.83)	0.38

The final model had 241 survivors and 61 patients with RRT dependence at hospital discharge; it did not demonstrate lack of goodness of fit (Hosmer-Lemeshow P = 0.69). CI, confidence interval; CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis; OR, odds ratio; RRT, renal replacement therapy; SLED, sustained low-efficiency dialysis; SOFA, sequential organ failure assessment score.

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