Variable | Whole cohort | Survivors | Non-survivors | P value |
---|---|---|---|---|
(n = 492) | (n = 241) | (n = 251) | ||
Demographics | ||||
Age, years | 62.9 (16.3) | 61.0 (16.6) | 64.7 (15.7) | 0.01 |
Male | 299 (60.8%) | 148 (61.4%) | 151 (60.2%) | 0.78 |
Weight, kg (n = 413, 197, 216) | 85.2 (24.3) | 86.2 (24.4) | 84.3 (24.2) | 0.43 |
Comorbidities | ||||
Charlson comorbidity index | 2 (1, 3) | 2 (1, 3) | 2 (1, 4) | <0.001 |
Congestive heart failure | 89 (18.1%) | 43 (17.8%) | 46 (18.3%) | 0.89 |
Liver cirrhosis | 20 (4.1%) | 4 (1.7%) | 16 (6.4%) | 0.01 |
Baseline creatinine, μmol/L (n = 490, 240, 250) | 123.5 (86, 206) | 136.5 (92, 223) | 110 (83, 190) | <0.001 |
Details of ICU admission | ||||
Admission type | ||||
Medical | 241 (49.0%) | 115 (47.7%) | 126 (50.2%) | 0.58 |
surgical | 251 (51.0%) | 126 (52.3%) | 125 (49.8%) | |
Cardiac surgery | 86 (17.5%) | 47 (19.5%) | 39 (15.5%) | 0.25 |
Aortic aneurysm repair | 29 (5.9%) | 19 (7.9%) | 10 (4.0%) | 0.07 |
Admission diagnosis (n = 485, 238, 247) | <0.001 | |||
Trauma | 25 (5.2%) | 15 (6.3%) | 10 (4.1%) | |
Cardiovascular | 198 (40.8%) | 106 (44.5%) | 92 (37.3%) | |
Respiratory | 59 (12.2%) | 24 (10.1%) | 35 (14.2%) | |
Gastrointestinal | 91 (18.8%) | 26 (10.9%) | 65 (26.3%) | |
Neurological | 11 (2.3%) | 6 (2.5%) | 5 (2.0%) | |
Renal | 54 (11.1%) | 37 (15.6%) | 17 (6.9%) | |
Other | 47 (9.7%) | 24 (10.1%) | 23 (9.3%) | |
SOFA on day of ICU admission (n = 347, 164, 183) | 12.1 (4.2) | 11.6 (4.2) | 12.5 (4.1) | 0.05 |
SOFA - cardiovascular on day of ICU admission (n = 341, 161, 180) | 3 (1, 4) | 3 (1, 4) | 3 (1, 4) | 0.17 |
Any vasopressor use on days 1-7 | 272 (55.3%) | 100 (41.5%) | 172 (68.5%) | <0.001 |
Details of RRT | ||||
SOFA on day RRT commenced (n = 490, 239, 251) | 14.2 (4.2) | 12.8 (3.9) | 15.6 (4.1) | <0.001 |
SOFA - cardiovascular on day RRT commenced (n = 490, 239, 251) | 3 (1, 4) | 3 (1, 4) | 4 (2, 4) | <0.001 |
Days from ICU admission to RRT | 2 (1, 5.5) | 2 (1, 4) | 2 (1, 7) | 0.002 |
Initial RRT modality | <0.001 | |||
IHD | 212 (43.1%) | 129 (53.5%) | 83 (33.1%) | |
sLED | 61 (12.4%) | 31 (12.9%) | 30 (12.0%) | |
CRRT | 219 (44.5%) | 81 (33.6%) | 138 (55.0%) | |
Days of RRT | 7 (4, 13) | 7 (4, 14) | 6 (3, 12) | 0.015 |
Mean daily fluid balance, mL | 708 (−69, 1805) | 413 (−371, 1106) | 1134 (242, 2556) | <0.001 |
Positive mean daily fluid balance on days 1-7 | 353 (71.7%) | 151 (62.7%) | 202 (80.5%) | <0.001 |
Intradialytic hypotension on any day (n = 490, 240, 250) | 428 (87.3%) | 194 (80.8%) | 234 (93.6%) | <0.001 |
Intradialytic hypotension (% days up to 7) (n = 490, 240, 250) | 50.0 (28.6, 80.0) | 42.9 (20.0, 66.7) | 66.7 (42.9, 100) | <0.001 |
Clinical outcomes | ||||
Days of ICU stay | 14 (7, 26.5) | 14 (7, 29) | 14 (8, 24) | 0.75 |
Days of hospital stay | 28 (15.5, 48) | 34 (23, 58) | 21 (11, 39) | <0.001 |