Skip to main content

Table 1 Characteristics of patients in the cohort

From: Fluid balance, intradialytic hypotension, and outcomes in critically ill patients undergoing renal replacement therapy: a cohort study

Variable

Whole cohort

Survivors

Non-survivors

P value

(n = 492)

(n = 241)

(n = 251)

Demographics

Age, years

62.9 (16.3)

61.0 (16.6)

64.7 (15.7)

0.01

Male

299 (60.8%)

148 (61.4%)

151 (60.2%)

0.78

Weight, kg (n = 413, 197, 216)

85.2 (24.3)

86.2 (24.4)

84.3 (24.2)

0.43

Comorbidities

 

Charlson comorbidity index

2 (1, 3)

2 (1, 3)

2 (1, 4)

<0.001

Congestive heart failure

89 (18.1%)

43 (17.8%)

46 (18.3%)

0.89

Liver cirrhosis

20 (4.1%)

4 (1.7%)

16 (6.4%)

0.01

Baseline creatinine, μmol/L (n = 490, 240, 250)

123.5 (86, 206)

136.5 (92, 223)

110 (83, 190)

<0.001

Details of ICU admission

 

Admission type

 

 Medical

241 (49.0%)

115 (47.7%)

126 (50.2%)

0.58

  surgical

251 (51.0%)

126 (52.3%)

125 (49.8%)

  Cardiac surgery

86 (17.5%)

47 (19.5%)

39 (15.5%)

0.25

  Aortic aneurysm repair

29 (5.9%)

19 (7.9%)

10 (4.0%)

0.07

Admission diagnosis (n = 485, 238, 247)

<0.001

  Trauma

25 (5.2%)

15 (6.3%)

10 (4.1%)

 

  Cardiovascular

198 (40.8%)

106 (44.5%)

92 (37.3%)

  Respiratory

59 (12.2%)

24 (10.1%)

35 (14.2%)

  Gastrointestinal

91 (18.8%)

26 (10.9%)

65 (26.3%)

  Neurological

11 (2.3%)

6 (2.5%)

5 (2.0%)

  Renal

54 (11.1%)

37 (15.6%)

17 (6.9%)

  Other

47 (9.7%)

24 (10.1%)

23 (9.3%)

SOFA on day of ICU admission (n = 347, 164, 183)

12.1 (4.2)

11.6 (4.2)

12.5 (4.1)

0.05

SOFA - cardiovascular on day of ICU admission (n = 341, 161, 180)

3 (1, 4)

3 (1, 4)

3 (1, 4)

0.17

Any vasopressor use on days 1-7

272 (55.3%)

100 (41.5%)

172 (68.5%)

<0.001

Details of RRT

SOFA on day RRT commenced (n = 490, 239, 251)

14.2 (4.2)

12.8 (3.9)

15.6 (4.1)

<0.001

SOFA - cardiovascular on day RRT commenced (n = 490, 239, 251)

3 (1, 4)

3 (1, 4)

4 (2, 4)

<0.001

Days from ICU admission to RRT

2 (1, 5.5)

2 (1, 4)

2 (1, 7)

0.002

Initial RRT modality

<0.001

  IHD

212 (43.1%)

129 (53.5%)

83 (33.1%)

 

 sLED

61 (12.4%)

31 (12.9%)

30 (12.0%)

  CRRT

219 (44.5%)

81 (33.6%)

138 (55.0%)

Days of RRT

7 (4, 13)

7 (4, 14)

6 (3, 12)

0.015

Mean daily fluid balance, mL

708 (−69, 1805)

413 (−371, 1106)

1134 (242, 2556)

<0.001

Positive mean daily fluid balance on days 1-7

353 (71.7%)

151 (62.7%)

202 (80.5%)

<0.001

Intradialytic hypotension on any day (n = 490, 240, 250)

428 (87.3%)

194 (80.8%)

234 (93.6%)

<0.001

Intradialytic hypotension (% days up to 7) (n = 490, 240, 250)

50.0 (28.6, 80.0)

42.9 (20.0, 66.7)

66.7 (42.9, 100)

<0.001

Clinical outcomes

 

Days of ICU stay

14 (7, 26.5)

14 (7, 29)

14 (8, 24)

0.75

Days of hospital stay

28 (15.5, 48)

34 (23, 58)

21 (11, 39)

<0.001

  1. Dichotomous data are of the form n (%) and continuous data of the form mean (SD) or median (Q1, Q3). The number of patients with data is provided where this differs from the total. P values are based on univariable logistic regression, except for days of ICU and hospital stay, days between ICU admission and RRT, and days of RRT, for which Wilcoxon signed-rank tests are reported. CRRT, continuous renal replacement therapy; ICU, intensive care unit; IHD, intermittent hemodialysis; RRT, renal replacement therapy; SLED, sustained low-efficiency dialysis; SOFA, sequential organ failure assessment score.