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Table 2 Emergency Department versus initial ICU performance of functional and structural biomarkers in acute kidney injury diagnosis

From: The clinical utility window for acute kidney injury biomarkers in the critically ill

Biomarkers

Emergency Department

ICU

P -value

Plasma creatinine

0.72 (0.61 to 0.83)

0.69 (0.57 to 0.81)

0.15

Plasma cystatin C

0.68 (0.56 to 0.80)

0.64 (0.52 to 0.77)

0.09

Plasma NGAL

0.75 (0.64 to 0.87)

0.80 (0.68 to 0.90)

0.37

Urinary NGAL

0.68 (0.55 to 0.82)

0.77 (0.66 to 0.88)

0.04

Urinary cystatin C

0.60 (0.45 to 0.74)

0.73 (0.61 to 0.85)

0.004

Urinary GGT

0.55 (0.40 to 0.70)

0.69 (0.56 to 0.82)

0.01

Urinary α-GST

0.32 (0.15 to 0.49)

0.32 (0.18 to 0.46)

0.79

Urinary α-GST

0.46 (0.28 to 0.65)

0.52 (0.37 to 0.67)

0.62

Urinary alkaline phosphatase

0.50 (0.35 to 0.65)

0.57 (0.43 to 0.71)

0.06

Urinary albumin

0.44 (0.29 to 0.59)

0.54 (0.40 to 0.68)

0.08

  1. Data expressed as area under curve with 95% confidence interval. NGAL, neutrophil gelatinase-associated lipocalin; GGT, gamma-glutamyltranspeptidase; GST, glutathione-S-transferase.