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Table 4 Predictors of receiving initially inappropriate antibiotic therapy a

From: Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study

 

Odds ratio

95% confidence interval

P value

Multidrug resistant

13.05

7.00-24.31

<0.001

HIV

3.64

1.02-12.95

0.046

Transferred from another hospital

2.86

2.00-4.08

<0.001

Nursing home resident

2.28

1.35-3.84

0.002

Prior antibiotics

2.06

1.47-2.87

<0.001

Polymicrobial

1.90

1.30-2.77

0.001

Congestive heart failure

1.61

1.11-2.35

0.013

APACHE II score (per 1 point)

1.05

1.02-1.07

<0.001

  1. aIndependent variables included but not retained in the model at alpha ≤0.05: age, admission source other than transfer from another hospital (home or nursing home), comorbidities of chronic obstructive pulmonary disease, chronic kidney disease, diabetes and malignancy, healthcare-associated infection risk factors hemodialysis, immune suppression and prior hospitalization, prior bacteremia, hospital length of stay prior to the onset of bacteremia, surgery, central line, total parenteral nutrition, septic shock, and infection source. APACHE, Acute Physiology and Chronic Health Evaluation. Area under the receiver operating characteristics curve = 0.738, Hosmer–Lemeshow P = 0.664.
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