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Table 2 Ability of pulse pressure variations to predict an increase of more than 15% in cardiac output after volume expansion according to tidal volume, driving pressure, respiratory compliance, heart rate/respiratory rate ratio and vasopressor use

From: Clinical relevance of pulse pressure variations for predicting fluid responsiveness in mechanically ventilated intensive care unit patients: the grey zone approach

 

AUC ROC 95% CI

Optimal threshold (%)

Gray zone

V T /IBW (ml/kg)

   

<8 (n = 280)

0.69 (0.64-0.73)

9

2-17

≥8 (n = 276)

0.77 (0.73-0.81)a

12

8-19

Driving pressure (cm H 2 0)

   

≤ 20 (n = 356)

0.67 (0.63-0.72)

7

3-17

>20 (n = 51)

0.78 (0.74-0.82)b

14

12-21

C st,rs (mL/cm H 2 0)

   

≤ 30 (n = 145)

0.60 (0.51-0.70)

12

2-21

>30 (n = 262)

0.73 (0.67-0.79)

7

3-17

HR/RR

   

≤ 3.6 (n = 114)

0.65 (0.54-0.76)

7

1-12

>3.6 (n = 384)

0.73 (0.68-0.78)

10

5-17

Vasopressor

   

Yes (n = 249)

0.70 (0.66-0.75)

14

3-16

No (n = 307)

0.72 (0.69-0.77)

10

6-18

  1. Data are presented as medians (95% confidence intervals). a: P <0.001 vs <8 ml.kg-1; b: P <0.001 vs ≤20 cm H20). AUC, area under the receiver operating characteristics curves, Cst,rs, static compliance of the respiratory system; HR/RR, heart rate/respiratory rate ratio; VT /IBW, tidal volume/ideal body weight ratio.