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Table 2 Ability of pulse pressure variations to predict an increase of more than 15% in cardiac output after volume expansion according to tidal volume, driving pressure, respiratory compliance, heart rate/respiratory rate ratio and vasopressor use

From: Clinical relevance of pulse pressure variations for predicting fluid responsiveness in mechanically ventilated intensive care unit patients: the grey zone approach

  AUC ROC 95% CI Optimal threshold (%) Gray zone
V T /IBW (ml/kg)    
<8 (n = 280) 0.69 (0.64-0.73) 9 2-17
8 (n = 276) 0.77 (0.73-0.81)a 12 8-19
Driving pressure (cm H 2 0)    
20 (n = 356) 0.67 (0.63-0.72) 7 3-17
>20 (n = 51) 0.78 (0.74-0.82)b 14 12-21
C st,rs (mL/cm H 2 0)    
30 (n = 145) 0.60 (0.51-0.70) 12 2-21
>30 (n = 262) 0.73 (0.67-0.79) 7 3-17
HR/RR    
3.6 (n = 114) 0.65 (0.54-0.76) 7 1-12
>3.6 (n = 384) 0.73 (0.68-0.78) 10 5-17
Vasopressor    
Yes (n = 249) 0.70 (0.66-0.75) 14 3-16
No (n = 307) 0.72 (0.69-0.77) 10 6-18
  1. Data are presented as medians (95% confidence intervals). a: P <0.001 vs <8 ml.kg-1; b: P <0.001 vs ≤20 cm H20). AUC, area under the receiver operating characteristics curves, Cst,rs, static compliance of the respiratory system; HR/RR, heart rate/respiratory rate ratio; VT /IBW, tidal volume/ideal body weight ratio.