Table 1 Characteristics of included GDFTdyn studies
Study | Type of surgery | Risk | Number of participants* | Timing | GDFTdyn end point | Other optimization goals | Type of intervention | Mortality reported | Morbidity reported |
|---|---|---|---|---|---|---|---|---|---|
Benes, 2010 [38] Europe | Major abdominal | High | 120 (60/60) | Intra | SVV <10% | CI >2.5 l/min/m2, MAP >65 mmHg, CVP <15 mmHg, | Fluids, inotropes | Y | CV, GI, infectious, renal, respiratory |
Buettner, 2008 [11] Europe | Major abdominal | Moderate | 80 (40/40) | Intra | SPV <10% | N/A | Fluids | Y | - |
Forget, 2010 [37] Europe | Abdominal | Moderate | 82 (41/41) | Intra | PVI <10% | MAP >65 mmHg | Fluids | Y | CV, GI, infectious, renal |
Goepfert, 2013 [36] Europe | Elective cardiac | High | 100 (50/50) | Intra, post | SVV <10% | CI >2.0 l/min/m2, MAP >65 mmHg, HR 50-100 bpm, EVLWI ≤12 ml/kg | Fluids, inotropes | N | CV, infectious, respiratory, renal |
Harten, 2008 [35] Europe | Emergency abdominal | High | 29 (15/14) | Intra | PPV <10% | N/A | Fluids | Y | CV, GI, infectious, renal, respiratory |
Kapoor, 2008 [39] India | Cardiac | High | 27 (14/13) | Intra, post | SVV <10% | CI >2.5 mL/min/m2, CVP >6 mmHg, ScvO2 > 70%, SVI >30 ml/m2, SVRI >1,500 dynes.s/cm5/m2, DO2I >450 mL/min/m2 | Fluids, inotropes | Y | GI, CV, renal, respiratory |
Lopes, 2007 [10] Brazil | Major abdominal | High | 33 (16/17) | Intra | PPV <10% | N/A | Fluids | Y | CV, GI, infectious, renal, respiratory |
Mayer, 2010 [40] Europe | Major abdominal | High | 60 (30/30) | Intra | SVV <12% | CI >2.5 mL/min/m2, MAP >65 mmHg, SVI >35 ml/m2 | Fluids, inotropes | Y | Renal, respiratory |
Ramsingh, 2013 [34] USA | Major abdominal | High | 38 (20/18) | Intra | SVV <13% | N/A | Fluids | N | - |
Salzwedel, 2013 [30] Europe | Elective abdominal | Moderate | 160 (81/79) | Intra | PPV <10% | CI >2.5 mL/min/m2, MAP >65 mmHg | Fluids, inotropes | N | CV, GI, infectious, renal, respiratory |
Sheeren, 2013 [33] Europe | Major abdominal | High | 52 (26/26) | Intra | SVV <10% | SV increase >10% | Fluids | Y | CV, GI, infectious, renal, respiratory |
Zhang Ju, 2012 [32] China | Major abdominal | Low | 60 (20/40) | Intra | PPV <11% | N/A | Fluids | N | CV, GI, infectious, renal, respiratory |
Zhang Ji, 2013 [31] China | Thoracic | Moderate | 60 (30/30) | Intra | SVV <9% | CI >2.5 mL/min/m2, MAP >65 mmHg | Fluids, inotropes | N | GI, infectious, renal, Respiratory |
Zheng, 2013 [29] China | Elective abdominal | Moderate | 60 (30/30) | Intra, post | SVV <12% | CI >2.5 mL/min/m2, MAP >65 mmHg, SVI >35 ml/m2 | Fluids, inotropes | N | CV, GI |