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Table 1 Characteristics of included GDFTdyn studies

From: The effects of goal-directed fluid therapy based on dynamic parameters on post-surgical outcome: a meta-analysis of randomized controlled trials

Study Type of surgery Risk Number of participants* Timing GDFTdyn end point Other optimization goals Type of intervention Mortality reported Morbidity reported
Benes, 2010 [38] Europe Major abdominal High 120 (60/60) Intra SVV <10% CI >2.5 l/min/m2, MAP >65 mmHg, CVP <15 mmHg, Fluids, inotropes Y CV, GI, infectious, renal, respiratory
Buettner, 2008 [11] Europe Major abdominal Moderate 80 (40/40) Intra SPV <10% N/A Fluids Y -
Forget, 2010 [37] Europe Abdominal Moderate 82 (41/41) Intra PVI <10% MAP >65 mmHg Fluids Y CV, GI, infectious, renal
Goepfert, 2013 [36] Europe Elective cardiac High 100 (50/50) Intra, post SVV <10% CI >2.0 l/min/m2, MAP >65 mmHg, HR 50-100 bpm, EVLWI ≤12 ml/kg Fluids, inotropes N CV, infectious, respiratory, renal
Harten, 2008 [35] Europe Emergency abdominal High 29 (15/14) Intra PPV <10% N/A Fluids Y CV, GI, infectious, renal, respiratory
Kapoor, 2008 [39] India Cardiac High 27 (14/13) Intra, post SVV <10% CI >2.5 mL/min/m2, CVP >6 mmHg, ScvO2 > 70%, SVI >30 ml/m2, SVRI >1,500 dynes.s/cm5/m2, DO2I >450 mL/min/m2 Fluids, inotropes Y GI, CV, renal, respiratory
Lopes, 2007 [10] Brazil Major abdominal High 33 (16/17) Intra PPV <10% N/A Fluids Y CV, GI, infectious, renal, respiratory
Mayer, 2010 [40] Europe Major abdominal High 60 (30/30) Intra SVV <12% CI >2.5 mL/min/m2, MAP >65 mmHg, SVI >35 ml/m2 Fluids, inotropes Y Renal, respiratory
Ramsingh, 2013 [34] USA Major abdominal High 38 (20/18) Intra SVV <13% N/A Fluids N -
Salzwedel, 2013 [30] Europe Elective abdominal Moderate 160 (81/79) Intra PPV <10% CI >2.5 mL/min/m2, MAP >65 mmHg Fluids, inotropes N CV, GI, infectious, renal, respiratory
Sheeren, 2013 [33] Europe Major abdominal High 52 (26/26) Intra SVV <10% SV increase >10% Fluids Y CV, GI, infectious, renal, respiratory
Zhang Ju, 2012 [32] China Major abdominal Low 60 (20/40) Intra PPV <11% N/A Fluids N CV, GI, infectious, renal, respiratory
Zhang Ji, 2013 [31] China Thoracic Moderate 60 (30/30) Intra SVV <9% CI >2.5 mL/min/m2, MAP >65 mmHg Fluids, inotropes N GI, infectious, renal, Respiratory
Zheng, 2013 [29] China Elective abdominal Moderate 60 (30/30) Intra, post SVV <12% CI >2.5 mL/min/m2, MAP >65 mmHg, SVI >35 ml/m2 Fluids, inotropes N CV, GI
  1. *Number of participants displayed as overall (control/intervention); complications. GDFTdyn: goal-directed fluid therapy based on dynamic parameters; SVV: stroke volume variation; CV: cardiovascular; GI: abdominal (gastrointestinal/liver); MAP: mean arterial pressure; CVP: central venous pressure; SPV: systolic pressure variation; N/A, not available; PVI: pleth variability index; CI: cardiac index; HR, heart rate; EVLWI: extravascular lung water index; PPV: pulse pressure variation; SVI: stroke volume index; SVRI: systemic vascular resistance index; ScvO2: central venous oxygen saturation; DO2I: oxygen delivery index.