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Table 3 Intervention-related AE

From: Rapid Induction of COOLing in Stroke Patients (iCOOL1): a randomised pilot study comparing cold infusions with nasopharyngeal cooling

ID Intervention Stroke type Intervention-related AE Subperiod Treatment
2 CI Ischaemic No - -
3 CI Ischaemic BSAS 3 II Yes
4 CI Ischaemic ΔSAP +42 mmHg, SAP 186 mmHg III Noa
6 CI ICH ΔSAP +33 mmHg III No
9 CI ICH ΔSAP +43 mmHg III No
13 CI Ischaemic ΔSAP +39 mmHg, ICP 27 mmHg II Yes
15 CI Ischaemic No - -
16 CI Ischaemic ΔSAP +43 mmHg III No
17 CI Ischaemic ΔSAP +28 mmHg III No
19 CI SAH ΔSAP +18 mmHg, SAP 165 mmHg IV Yes
1 NPC Ischaemic ΔSAP +35 mmHg I No
5 NPC ICH No - -
7 NPC ICH BSAS 3 I Yes
8 NPC SAH ΔSAP +14 mmHg, SAP 160 mmHg I Yes
10 NPC Ischaemic ΔSAP +28 mmHg, SAP 187 mmHg I Yes
11 NPC ICH ΔSAP +40 mmHg I No
12 NPC Ischaemic ΔSAP +51 mmHg, ICP 27 mmHg I Yes
14 NPC ICH No - -
18 NPC ICH No - -
20 NPC Ischaemic ΔSAP +25 mmHg I No
  1. aSAP rose to 186 mmHg, but resolved spontaneously before treatment was initiated. Intervention-related AE of neurovital parameters for each patient, with the time of occurrence (subperiods I to IV), and whether or not the AE was treated. Treatment was indicated if SAP or ICP was higher than the predefined critical value (SAP ischaemic stroke ≥180 mmHg, haemorrhagic stroke ≥160 mmHg; ICP ≥20 mmHg), or the BSAS score was ≥1. ΔSAP indicates maximum delta SAP compared to baseline. BSAS, Bedside Shivering Assessment Scale; ICH, intracerebral haemorrhage; ICP, intracranial pressure; SAH, subarachnoid haemorrhage; SAP, systolic arterial pressure.