Rapid Induction of COOLing in Stroke Patients (iCOOL1): a randomised pilot study comparing cold infusions with nasopharyngeal cooling

Table 3 Intervention-related AE

ID	Intervention	Stroke type	Intervention-related AE	Subperiod	Treatment
2	CI	Ischaemic	No	-	-
3	CI	Ischaemic	BSAS 3	II	Yes
4	CI	Ischaemic	ΔSAP +42 mmHg, SAP 186 mmHg	III	No^a
6	CI	ICH	ΔSAP +33 mmHg	III	No
9	CI	ICH	ΔSAP +43 mmHg	III	No
13	CI	Ischaemic	ΔSAP +39 mmHg, ICP 27 mmHg	II	Yes
15	CI	Ischaemic	No	-	-
16	CI	Ischaemic	ΔSAP +43 mmHg	III	No
17	CI	Ischaemic	ΔSAP +28 mmHg	III	No
19	CI	SAH	ΔSAP +18 mmHg, SAP 165 mmHg	IV	Yes
1	NPC	Ischaemic	ΔSAP +35 mmHg	I	No
5	NPC	ICH	No	-	-
7	NPC	ICH	BSAS 3	I	Yes
8	NPC	SAH	ΔSAP +14 mmHg, SAP 160 mmHg	I	Yes
10	NPC	Ischaemic	ΔSAP +28 mmHg, SAP 187 mmHg	I	Yes
11	NPC	ICH	ΔSAP +40 mmHg	I	No
12	NPC	Ischaemic	ΔSAP +51 mmHg, ICP 27 mmHg	I	Yes
14	NPC	ICH	No	-	-
18	NPC	ICH	No	-	-
20	NPC	Ischaemic	ΔSAP +25 mmHg	I	No

^aSAP rose to 186 mmHg, but resolved spontaneously before treatment was initiated. Intervention-related AE of neurovital parameters for each patient, with the time of occurrence (subperiods I to IV), and whether or not the AE was treated. Treatment was indicated if SAP or ICP was higher than the predefined critical value (SAP ischaemic stroke ≥180 mmHg, haemorrhagic stroke ≥160 mmHg; ICP ≥20 mmHg), or the BSAS score was ≥1. ΔSAP indicates maximum delta SAP compared to baseline. BSAS, Bedside Shivering Assessment Scale; ICH, intracerebral haemorrhage; ICP, intracranial pressure; SAH, subarachnoid haemorrhage; SAP, systolic arterial pressure.

ISSN: 1364-8535