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Table 6 Interrupted time series analysis for length of mechanical ventilation and midazolam consumption a

From: Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project

  Average crude data Modeled data from hierarchical time series
  Length of MV (days) Midazolam consumption (mg/day of MV) Length of MV (days) Midazolam consumption (mg/day of MV)
  β SE P-value β SE P-value β SE P-value β SE P-value
Constant (β0) 4.369 0.169 <0.001 383.5 30.3 <0.001 52.608 3.426 <0.001 5406.7 488.7 <0.001
Secular trend (β1) -0.055 0.019 0.012 -8.585 3.77 0.038 -1.011 0.396 0.023 -199.4 60.8 0.005
Intervention (β2) -0.976 0.067 <0.001 -0.045 1.017 0.97 -0.979 0.158 <0.001 -0.431 0.926 0.65
Postintervention trend (β3) 0.039 0.022 0.095 -19.457 5.93 0.005 1.080 0.545 0.068 -183.9 74.3 0.026
  1. aMV, Mechanical ventilation.