Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project

Table 6 Interrupted time series analysis for length of mechanical ventilation and midazolam consumption ^a

	Average crude data						Modeled data from hierarchical time series
	Length of MV (days)			Midazolam consumption (mg/day of MV)			Length of MV (days)			Midazolam consumption (mg/day of MV)
	β	SE	P-value	β	SE	P-value	β	SE	P-value	β	SE	P-value
Constant (β₀)	4.369	0.169	<0.001	383.5	30.3	<0.001	52.608	3.426	<0.001	5406.7	488.7	<0.001
Secular trend (β₁)	-0.055	0.019	0.012	-8.585	3.77	0.038	-1.011	0.396	0.023	-199.4	60.8	0.005
Intervention (β₂)	-0.976	0.067	<0.001	-0.045	1.017	0.97	-0.979	0.158	<0.001	-0.431	0.926	0.65
Postintervention trend (β₃)	0.039	0.022	0.095	-19.457	5.93	0.005	1.080	0.545	0.068	-183.9	74.3	0.026

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