
Average crude data

Modeled data from hierarchical time series



Length of MV (days)

Midazolam consumption (mg/day of MV)

Length of MV (days)

Midazolam consumption (mg/day of MV)



β

SE

Pvalue

β

SE

Pvalue

β

SE

Pvalue

β

SE

Pvalue


Constant (β_{0})

4.369

0.169

<0.001

383.5

30.3

<0.001

52.608

3.426

<0.001

5406.7

488.7

<0.001

Secular trend (β_{1})

0.055

0.019

0.012

8.585

3.77

0.038

1.011

0.396

0.023

199.4

60.8

0.005

Intervention (β_{2})

0.976

0.067

<0.001

0.045

1.017

0.97

0.979

0.158

<0.001

0.431

0.926

0.65

Postintervention trend (β_{3})

0.039

0.022

0.095

19.457

5.93

0.005

1.080

0.545

0.068

183.9

74.3

0.026

 ^{a}MV, Mechanical ventilation.